CAJ | 학술논문

目的：探讨川崎病患儿发病第1周(治疗前)、第2~3周(治疗后)血小板参数和 C 反应蛋白的变化及临床意义。方法对42例川崎病患儿(观察组)及30例同期体检健康儿童(对照组)取空腹静脉血测定血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、和血小板分布宽度(PDW)及 C 反应蛋白,对观察组及对照组血小板参数和 C 反应蛋白进行比较,并对上述参数与有无冠状动脉病变进行比较。结果川崎病患儿在发病第1周PLT、MPV、PDW 均明显高于对照组,给予治疗后,MPV 和 PDW 均较治疗前降低。治疗前有无冠状动脉病变川崎病患儿 PLT 和 C 反应蛋白差异无统计学意义,治疗后无冠状动脉病变组 MPV、PCT、PDW 和 C 反应蛋白均较冠状动脉病变组减少,差异具有统计学意义。结论血小板参数和 C 反应蛋白在川崎病的发病中具有重要的意义,对评估患儿病情及指导临床用药具有重要的作用。
목적：탐토천기병환인발병제1주(치료전)、제2~3주(치료후)혈소판삼수화 C 반응단백적변화급림상의의。방법대42례천기병환인(관찰조)급30례동기체검건강인동(대조조)취공복정맥혈측정혈소판계수(PLT)、혈소판평균체적(MPV)、혈소판압적(PCT)、화혈소판분포관도(PDW)급 C 반응단백,대관찰조급대조조혈소판삼수화 C 반응단백진행비교,병대상술삼수여유무관상동맥병변진행비교。결과천기병환인재발병제1주PLT、MPV、PDW 균명현고우대조조,급여치료후,MPV 화 PDW 균교치료전강저。치료전유무관상동맥병변천기병환인 PLT 화 C 반응단백차이무통계학의의,치료후무관상동맥병변조 MPV、PCT、PDW 화 C 반응단백균교관상동맥병변조감소,차이구유통계학의의。결론혈소판삼수화 C 반응단백재천기병적발병중구유중요적의의,대평고환인병정급지도림상용약구유중요적작용。
ABSTRACT:Objective To investigate the clinical significance of platelet parameters and the variation of C reactive protein on the first week onset of Kawasaki disease(before therapy)and two to three weeks (after therapy). Methods 42 cases of children with Kawasaki disease and 30 cases of the healthy children examined at the same period (control group)were enrolled in the study.Blood platelet (PLT),mean platelet volume (MPV),platelet hematocrit (PCT),and platelet distribution width (PDW )and C-reactive protein were detected in these patients.The difference of platelet parameters and C-reactive protein were compared between Kawasaki disease group and control group.These parameters were also compared between coronary artery disease and without coronary artery disease patients.Results At the first week onset of Kawasaki disease,the parameters of PLT,MPV and PDW in Kawasaki disease group were significantly higher than control group.After the administration of treatment,MPV and PDW were lower than those before the treatment.Before treatment no significant differences of platelet parameters and C-reactive protein were found in Kawasaki disease children with absence of coronary artery dissease. However, after administration of treatment,MPV,PCT,PDW and C-reactive protein were lower in the group without coronary atery lesions than those with coronary artery disease in Kawasaki disease children.Conclusion Platelet parameters and C-reactive protein exerted great significance in the pathogenesis of Kawasaki disease in children which might play an important roles in assessing the development and selecting clinical therapy.