CAJ | 학술논문

目的探讨氢质子磁共振波谱( 1 H-MRS)对病毒性脑炎和脑低级别胶质瘤的鉴别诊断价值.方法使用飞利浦3.0 T MR系统对低级别胶质瘤(胶质瘤组)20例, 病毒性脑炎(脑炎组)25例进行常规MRI平扫和增强扫描,所有病例均在病灶区及相应正常脑实质区设置感兴趣区进行1 H-MRS 成像. 利用Function Tool软件对波谱数据进行分析,分别检测病灶侧和对侧相应正常脑区MRS的N-乙酰天门冬氨酸( NAA)、肌酸( Cr)、胆碱( Cho)值,并进行比较. 结果两组正常侧与相应部位病灶侧的Cho/Cr、Cho/NAA、NAA/Cho、NAA/Cr比较差异有统计学意义(均P<0.01 ). 两组间病灶侧Cho/Cr、Cho/NAA、NAA/Cho比较差异有统计学意义(均P<0.01). 两组间正常侧Cho/Cr、Cho/NAA、NAA/Cho、NAA/Cr比较差异无统计学意义(均P>0.05). Cho/Cr的ROC曲线下面积为0.926,其中Cho/Cr取界值为2.46时,鉴别脑低级别胶质瘤与病毒性脑炎的灵敏度为91.7%,特异度为88.9%. 结论 1 H-MRS对病毒性脑炎和脑低级别胶质瘤的鉴别诊断有重要临床价值,其中以Cho/Cr比值鉴别二者的参考价值最大.
목적 탐토경질자자공진파보( 1 H-MRS)대병독성뇌염화뇌저급별효질류적감별진단개치.방법 사용비리포3.0 T MR계통대저급별효질류(효질류조)20례, 병독성뇌염(뇌염조)25례진행상규MRI평소화증강소묘,소유병례균재병조구급상응정상뇌실질구설치감흥취구진행1 H-MRS 성상. 이용Function Tool연건대파보수거진행분석,분별검측병조측화대측상응정상뇌구MRS적N-을선천문동안산( NAA)、기산( Cr)、담감( Cho)치,병진행비교. 결과 량조정상측여상응부위병조측적Cho/Cr、Cho/NAA、NAA/Cho、NAA/Cr비교차이유통계학의의(균P<0.01 ). 량조간병조측Cho/Cr、Cho/NAA、NAA/Cho비교차이유통계학의의(균P<0.01). 량조간정상측Cho/Cr、Cho/NAA、NAA/Cho、NAA/Cr비교차이무통계학의의(균P>0.05). Cho/Cr적ROC곡선하면적위0.926,기중Cho/Cr취계치위2.46시,감별뇌저급별효질류여병독성뇌염적령민도위91.7%,특이도위88.9%. 결론 1 H-MRS대병독성뇌염화뇌저급별효질류적감별진단유중요림상개치,기중이Cho/Cr비치감별이자적삼고개치최대.
Objective To explore the differential diagnostic value of Hydrogen proton magnetic resonance spectroscopy (1H-MRS) on brain low-grade glioma and viral encephalitis.Methods Twenty patients with brain low-grade gliomas ( gliomas group) and 25 patients with viral encephalitis ( encephalitis group) were given conventional MRI scan and enhanced scan by Philips 3.0 T MR system.All cases were set interested area in lesion site and normal by single vovel proton spectroscopic imaging.The spectral data was analyzed by Function Tool software, ipsilateral and contralateral normal brain MRS of N-acetyl aspartate ( NAA) , creatine ( Cr) , choline ( Cho) value were detected and compared.Results The differences of Cho/Cr, Cho/NAA, NAA/Cho, NAA/Cr between the normal side and the corresponding lesion side of the two groups were statistical significant ( all P<0.01) .The differences of Cho/Cr, Cho/NAA, NAA/Cho of the lesion side between the two groups were statistical significant ( all P<0.01 ) .The differences of Cho/Cr, Cho/NAA, NAA/Cho, NAA/Cr of the normal side between the two groups were no statistical significant ( all P>0.05) .The area under the ROC curve of Cho/Cr was 0.926; when Cho/Cr take the cutoff as 2.46, the sensitivity of identification between brain low-grade glioma and viral encephalitis was 91.7%, and the specificity was 88.9%.Conclusions 1 H-MRS has important clinical value for differential diagnosis of brain low-grade gliomas and viral encephalitis.The ratio of Cho/Cr on identify the two disease has the largest reference value.