CAJ | 학술논문

目的：：观察自身免疫抗体甲状腺球蛋白抗体( TGAb)、抗甲状腺过氧化物酶抗体( TPOAb)和促甲状腺素受体抗体( TRAb)在4种甲状腺疾病中的水平差异。方法：将2012年1月至2014年6月在佛山市中医院内分泌科门诊就诊的506例4种甲状腺疾病患者作为研究对象，定量检测患者血液中TGAb、TPOAb和TRAb抗体水平。结果：桥本甲状腺炎患者血液中TGAb和TPOAb值、阳性率最高，分别为1439.0 IU/mL、87.7％和427.5 IU/mL、97.7％；Graves病患者血液中TRAb值和阳性率最高，为34.44 IU/L和100％；单纯性甲状腺肿及亚急性甲状腺炎患者血液中，甲状腺自身免疫抗体也有不同程度的升高。4种甲状腺疾病患者TGAb、TPOAb和TRAb抗体水平两两比较，除了亚急性甲状腺炎与桥本甲状腺炎患者的TRAb水平外，差异均有统计学意义( P<0.05)。结论：甲状腺自身免疫抗体TGAb、TPOAb和TRAb水平在不同甲状腺疾病中存在差异，结合分析对于甲状腺疾病尤其是自身免疫性甲状腺疾病具有重要的诊断价值。
목적：：관찰자신면역항체갑상선구단백항체( TGAb)、항갑상선과양화물매항체( TPOAb)화촉갑상선소수체항체( TRAb)재4충갑상선질병중적수평차이。방법：장2012년1월지2014년6월재불산시중의원내분비과문진취진적506례4충갑상선질병환자작위연구대상，정량검측환자혈액중TGAb、TPOAb화TRAb항체수평。결과：교본갑상선염환자혈액중TGAb화TPOAb치、양성솔최고，분별위1439.0 IU/mL、87.7％화427.5 IU/mL、97.7％；Graves병환자혈액중TRAb치화양성솔최고，위34.44 IU/L화100％；단순성갑상선종급아급성갑상선염환자혈액중，갑상선자신면역항체야유불동정도적승고。4충갑상선질병환자TGAb、TPOAb화TRAb항체수평량량비교，제료아급성갑상선염여교본갑상선염환자적TRAb수평외，차이균유통계학의의( P<0.05)。결론：갑상선자신면역항체TGAb、TPOAb화TRAb수평재불동갑상선질병중존재차이，결합분석대우갑상선질병우기시자신면역성갑상선질병구유중요적진단개치。
Objective:To determine the different levels of the thyroid autoimmune antibodies, including thyroglobulin antibody (TGAb) and antithyroid peroxidase antibody (TPOAb) and thyroid stimulating hormone receptor antibody ( TRAb) in four kinds of thyroid diseases. Methods:A total of 506 patients with four kinds of thyroid diseases, who were hospitalized in Department of Endocrinology, Foshan Hospital of Traditional Chinese Medicine between January 2012 and June 2014, were included as the subjects in the study. The levels of plasma TGAb, TPOAb and TRAb antibodies in all patients were quantitatively determined. Results: The values and positive rates of plasma TGAb and TPOAb in patients with Hashimoto thyroiditis were the highest, which were 1439.0IU/ml, 87.7% and 427.5IU/ml, 97.7%, respectively. The plasma TRAb value and positive rate were the highest in patients with Graves, which were 34.44IU/L and 100%, respectively. The plasma thyroid autoimmune antibodies in patients with simple goiter and subacute thyroiditis were increased in different degrees. There were statistically significant differences in TGAb, TPOAb and TRAb antibody levels among patients with four kinds of thyroid diseases in pairs (P<0.05), whereas no statistically significant difference was found in TRAb antibody level between patients with subacute thyroiditis and Hashimoto thyroiditis. Conclusion: There are differences in thyroid autoimmune antibodies TGAb, TPOAb and TRAb levels between different thyroid diseases. Combined analysis of the thyroid diseases, especially thyroid autoimmune disease, has significantly diagnostic value.