临床神经病学杂志
臨床神經病學雜誌
림상신경병학잡지
Journal of Clinical Neurology
2015年
5期
338-340
,共3页
孙涛%余年%张燕芳%陈艳%尹延肖%狄晴
孫濤%餘年%張燕芳%陳豔%尹延肖%狄晴
손도%여년%장연방%진염%윤연초%적청
丙泊酚%巴比妥类%咪达唑仑%难治性癫痫持续状态%Meta分析
丙泊酚%巴比妥類%咪達唑崙%難治性癲癇持續狀態%Meta分析
병박분%파비타류%미체서륜%난치성전간지속상태%Meta분석
propofol%barbiturates%midazolam%refractory status epilepticus%Meta-analysis
目的 探讨丙泊酚治疗难治性癫痫持续状态( RSE)的疗效及安全性. 方法 计算机检索CBM (1985~2014.7)、WanFang Data(1982~2014.7)、VIP(1989~2014.7)、CNKI(1979~2014.7)、PubMed(1966~2014.7)、Embase(1974~2014.7),根据纳入、排除标准选择有关丙泊酚治疗RSE的对照试验,并提取有效数据,采用RevMan 5.3软件进行分析. 结果 共纳入5个有效研究,合计111例患者. Meta分析结果显示,丙泊酚组治疗RSE的癫痫控制率总体上优于对照组(OR=2.44, 95%CI:1.05~5.66, P=0.04),但二者死亡率的差异无统计学意义(OR=1.19, 95%CI:0.55~2.61, P=0.66). 结论 丙泊酚可有效控制RSE发作,但并不降低其死亡率.
目的 探討丙泊酚治療難治性癲癇持續狀態( RSE)的療效及安全性. 方法 計算機檢索CBM (1985~2014.7)、WanFang Data(1982~2014.7)、VIP(1989~2014.7)、CNKI(1979~2014.7)、PubMed(1966~2014.7)、Embase(1974~2014.7),根據納入、排除標準選擇有關丙泊酚治療RSE的對照試驗,併提取有效數據,採用RevMan 5.3軟件進行分析. 結果 共納入5箇有效研究,閤計111例患者. Meta分析結果顯示,丙泊酚組治療RSE的癲癇控製率總體上優于對照組(OR=2.44, 95%CI:1.05~5.66, P=0.04),但二者死亡率的差異無統計學意義(OR=1.19, 95%CI:0.55~2.61, P=0.66). 結論 丙泊酚可有效控製RSE髮作,但併不降低其死亡率.
목적 탐토병박분치료난치성전간지속상태( RSE)적료효급안전성. 방법 계산궤검색CBM (1985~2014.7)、WanFang Data(1982~2014.7)、VIP(1989~2014.7)、CNKI(1979~2014.7)、PubMed(1966~2014.7)、Embase(1974~2014.7),근거납입、배제표준선택유관병박분치료RSE적대조시험,병제취유효수거,채용RevMan 5.3연건진행분석. 결과 공납입5개유효연구,합계111례환자. Meta분석결과현시,병박분조치료RSE적전간공제솔총체상우우대조조(OR=2.44, 95%CI:1.05~5.66, P=0.04),단이자사망솔적차이무통계학의의(OR=1.19, 95%CI:0.55~2.61, P=0.66). 결론 병박분가유효공제RSE발작,단병불강저기사망솔.
Objective To evaluate the efficacy and safety of propofol for refractory statue epilepticus (RSE). Methods Controlled trials associated with RSE were searched from the database of CBM ( 1985 -2014.7 ) , WanFang (1982-2014.7), VIP (1989-2014.7), CNKI (1979-2014.7), PubMed (1966-2014.7), Embase (1974-2014.7), and the related references were picked up by inclusion and exculsion criteria and traced to obtain the information.Meta-analysis was performed using RevMan 5.3 software.Results Totally 5 studies involving 111 patients were included.Meta-analysis showed that the epilepsy control rate of propofol group on treating RSE was significantly more effective than control group (OR =2.44, 95%CI: 1.05 -5.66, P=0.04).However, the mortality was no statistical difference (OR=1.19, 95%CI: 0.55 -2.61, P=0.66).Conclusion Propofol is effective to control RSE, but can not reduce its mortality rate.
