广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2015年
4期
51-53
,共3页
尘肺%中性粒细胞明胶酶相关脂质运载蛋白( NGAL)%肿瘤坏死因子α( TNF-α)
塵肺%中性粒細胞明膠酶相關脂質運載蛋白( NGAL)%腫瘤壞死因子α( TNF-α)
진폐%중성립세포명효매상관지질운재단백( NGAL)%종류배사인자α( TNF-α)
pneumoconiosis%neutrophil gelatinase associated lipocalin ( NGAL)%tumor necrosis factor-α( TNF-α)
目的：：通过检测尘肺患者血清和尿液中性粒细胞明胶酶相关脂质运载蛋白( NGAL)的表达水平,探讨NGAL在尘肺病的临床诊断价值。方法：选取本院确诊为尘肺的患者38例,分别监测患者入院后6、12、24和48 h血清NGAL(sNGAL)、尿液NGAL(uNGAL)、血TNF-α的水平变化,并绘制 sNGAL、uNGAL对于尘肺诊断受试者工作特征曲线( ROC曲线)；同时选取20例作健康对照组。结果：尘肺患者sNGAL、uNGAL、TNF-α水平均显著高于健康对照组( P<0.05)；尘肺患者sNGAL、uNGAL升高水平与TNF-α水平呈均正相关(r1＝0.857,r2＝0.619,P均<0.05),sNGAL的表达水平在12 h达到高峰,而uNGAL在24h才达到高峰；sNGAL对尘肺诊断的敏感性及特异性分别为89.3％和75.7％,而uNGAL为63.2％和78.5％。结论：NGAL有可能成为早期判断尘肺的生物标志物,监测sNGAL和uNGAL水平可能有助于尘肺的早期诊断。
目的：：通過檢測塵肺患者血清和尿液中性粒細胞明膠酶相關脂質運載蛋白( NGAL)的錶達水平,探討NGAL在塵肺病的臨床診斷價值。方法：選取本院確診為塵肺的患者38例,分彆鑑測患者入院後6、12、24和48 h血清NGAL(sNGAL)、尿液NGAL(uNGAL)、血TNF-α的水平變化,併繪製 sNGAL、uNGAL對于塵肺診斷受試者工作特徵麯線( ROC麯線)；同時選取20例作健康對照組。結果：塵肺患者sNGAL、uNGAL、TNF-α水平均顯著高于健康對照組( P<0.05)；塵肺患者sNGAL、uNGAL升高水平與TNF-α水平呈均正相關(r1＝0.857,r2＝0.619,P均<0.05),sNGAL的錶達水平在12 h達到高峰,而uNGAL在24h纔達到高峰；sNGAL對塵肺診斷的敏感性及特異性分彆為89.3％和75.7％,而uNGAL為63.2％和78.5％。結論：NGAL有可能成為早期判斷塵肺的生物標誌物,鑑測sNGAL和uNGAL水平可能有助于塵肺的早期診斷。
목적：：통과검측진폐환자혈청화뇨액중성립세포명효매상관지질운재단백( NGAL)적표체수평,탐토NGAL재진폐병적림상진단개치。방법：선취본원학진위진폐적환자38례,분별감측환자입원후6、12、24화48 h혈청NGAL(sNGAL)、뇨액NGAL(uNGAL)、혈TNF-α적수평변화,병회제 sNGAL、uNGAL대우진폐진단수시자공작특정곡선( ROC곡선)；동시선취20례작건강대조조。결과：진폐환자sNGAL、uNGAL、TNF-α수평균현저고우건강대조조( P<0.05)；진폐환자sNGAL、uNGAL승고수평여TNF-α수평정균정상관(r1＝0.857,r2＝0.619,P균<0.05),sNGAL적표체수평재12 h체도고봉,이uNGAL재24h재체도고봉；sNGAL대진폐진단적민감성급특이성분별위89.3％화75.7％,이uNGAL위63.2％화78.5％。결론：NGAL유가능성위조기판단진폐적생물표지물,감측sNGAL화uNGAL수평가능유조우진폐적조기진단。
Objective:To determine the expression level of serum and urine neutrophil gelatinase associated lipocalin ( NGAL) in patients with pneumoconiosis, and to investigate the clinical value of NGAL in the diagnosis of pneumoconiosis. Methods: Thirty-eight patients diagnosed with pneumoconiosis were included in the study. The level changes of serum NGAL (sNGAL) and urine NGAL (uNGAL), and plasma tumor necrosis factor-α( TNF-α) at 6, 12, 24, and 48h after hospitalization were monitored, respectively. The receiver operating characteristic ( ROC ) curves of sNGAL and uNGAL on the diagnosis of pneumoconiosis were drawn. A contemporary cohort of 20 healthy volunteers was included in the control group. Results: The levels of sNGAL, uNGAL and TNF-α in patients with pneumoconiosis were significantly higher than those in the healthy controls ( P<0. 05 ) . The increasing levels of sNGAL and uNGAL in patients with pneumoconiosis were positively correlated with TNF-α (r1=0.857, r2= 0.619, all P<0.05). The expression level of sNGAL peaked at 12h, while uNGAL peaked at 24h. The sensitivity and specificity of sNGAL in the diagnosis of pneumoconiosis were 89.3% and 75. 7%, while uNGAL were 63. 2% and 78. 5%, respectively. Conclusions: NGAL may be a biomarker for early diagnosis of pneumoconiosis, and monitoring sNGAL and uNGAL levels may contribute to early diagnosis of pneumoconiosis.
