CAJ | 학술논문

端粒酶是细胞中负责端粒延长的一种酶，通过合成染色体末端的DNA赋予细胞复制的永生性。其在保持端粒稳定、基因组完整、细胞长期的活性和潜在的继续增殖能力等方面有重要作用，端粒/端粒酶复合物的结构和功能的改变将会导致不同的疾病，尤其是癌症的发生。在人类正常生殖细胞、早期胚胎、干细胞、高度增殖体细胞和许多癌细胞中均有不同程度的端粒酶活性表达，并受到严密的调控。在女性生殖功能调控下，端粒酶活性表达在卵泡的发育及闭锁、子宫内膜的周期性变化、卵巢储备功能及性激素调节等方面发挥着重要的作用，并可在一定程度上预测卵巢储备功能及体外受精妊娠结局。
단립매시세포중부책단립연장적일충매，통과합성염색체말단적DNA부여세포복제적영생성。기재보지단립은정、기인조완정、세포장기적활성화잠재적계속증식능력등방면유중요작용，단립/단립매복합물적결구화공능적개변장회도치불동적질병，우기시암증적발생。재인류정상생식세포、조기배태、간세포、고도증식체세포화허다암세포중균유불동정도적단립매활성표체，병수도엄밀적조공。재녀성생식공능조공하，단립매활성표체재란포적발육급폐쇄、자궁내막적주기성변화、란소저비공능급성격소조절등방면발휘착중요적작용，병가재일정정도상예측란소저비공능급체외수정임신결국。
Telomerase is an enzyme which is responsible for the extension of telomeres. By synthesizing DNA ends of chromosomes, it can confer cell replication immortality, which plays an important role in maintaining telomere stability, genomic integrity, cell activity and potential long-term proliferative ability. To change the structure and function of telomere/telomerase complex behavior may result in different diseases, especially the cancer. The expression of telomerase activity has different levels in normal human germ cells, early embryos, stem cells, highly proliferative cells and many cancer cells, and telomerase activity has been shown very strict regulation. Under the regulation of female reproductive function, telomerase activity plays an important role in follicular development and atresia, cyclical changes in endometrial, ovarian reserve and regulate hormones, etc., and to a certain extent, it can predict ovarian reserve function and IVF pregnancy outcome.