CAJ | 학술논문

近年来，肥胖症发病率持续上升，育龄妇女的超重和肥胖问题也日渐突出，已成为全球关注的焦点之一。肥胖可引起心脑血管疾病、肿瘤、糖尿病、肾病等一系列疾病，与此同时，大量证据表明妊娠期肥胖会对子代发育产生潜在和长期的不良影响。过去的研究多集中于肥胖母体对子代内分泌代谢的影响，而最近的流行病学调查和动物实验发现，母体肥胖与其子代多种神经系统疾病和精神疾病之间也存在显著关联，如子代智力障碍、精神分裂症、孤独症、焦虑症及阿尔茨海默病等。对母体肥胖与子代神经和精神疾病的相关性及发病机制进行综述，这对于在肥胖母体的子代中该类疾病的预防、诊断及治疗具有重要的临床价值和积极的社会意义。
근년래，비반증발병솔지속상승，육령부녀적초중화비반문제야일점돌출，이성위전구관주적초점지일。비반가인기심뇌혈관질병、종류、당뇨병、신병등일계렬질병，여차동시，대량증거표명임신기비반회대자대발육산생잠재화장기적불량영향。과거적연구다집중우비반모체대자대내분비대사적영향，이최근적류행병학조사화동물실험발현，모체비반여기자대다충신경계통질병화정신질병지간야존재현저관련，여자대지력장애、정신분렬증、고독증、초필증급아이자해묵병등。대모체비반여자대신경화정신질병적상관성급발병궤제진행종술，저대우재비반모체적자대중해류질병적예방、진단급치료구유중요적림상개치화적겁적사회의의。
In recent years, the global prevalence of obesity continues to rise and the problem of overweight and obesity among women of childbearing age has become more prominent, leading to worldwide attention. Obesity can contribute to a series of diseases, such as cardiovascular disease, cancer, diabetes, kidney disease, etc. At the same time, more and more evidences indicated that maternal obesity might have potential and long-term adverse effects on the development of their offspring. Previous studies mainly focused on the endocrine changes in maternal obesity -related offspring, whereas some epidemiological investigations and animal model studies have recently shown the correlations between maternal obesity and nervous and mental diseases in its offspring. This article provides an overview of the effects of maternal obesity on the nervous and mental system in the offspring, including the occurrence and development of intellectual disability, schizophrenia, autism, anxiety, and Alzheimer′s disease. Additionally, it can elucidate the correlative mechanism, which would have crucial clinical and social significance in the prevention, diagnosis and treatment of the nervous and mental diseases for maternal obesity-related offspring.