中国医药指南
中國醫藥指南
중국의약지남
Guide of China Medicine
2015年
29期
22-23
,共2页
刘颖%张勤勇%何兴坤%刘瑜
劉穎%張勤勇%何興坤%劉瑜
류영%장근용%하흥곤%류유
山楂%苞叶雪莲%防辐射损伤%微核试验
山楂%苞葉雪蓮%防輻射損傷%微覈試驗
산사%포협설련%방복사손상%미핵시험
Crataegus%Saussurea obvallata%Radiation damage%Micronucleus test
目的 研究山楂和苞叶雪莲水提物对小鼠的防辐射作用.方法 选择40只小鼠作为研究对象,随机分配到空白组、造模组、山楂组、苞叶雪莲进行实验,造模组、山楂组、苞叶雪莲分别给以相同剂量的0.9%生理盐水、山楂水提物和苞叶雪莲水提物,灌胃14 d后接受4 Gy的X线一次性全身照射,24 h后处死小鼠,测量小鼠骨髓细胞微核率.结果 山楂组和苞叶雪莲组微核率均低于造模组,差异均有统计学意义,P<0.05.结论 山楂及苞叶雪莲水提物中的活性成分对小鼠有一定程度的防辐射损伤作用.
目的 研究山楂和苞葉雪蓮水提物對小鼠的防輻射作用.方法 選擇40隻小鼠作為研究對象,隨機分配到空白組、造模組、山楂組、苞葉雪蓮進行實驗,造模組、山楂組、苞葉雪蓮分彆給以相同劑量的0.9%生理鹽水、山楂水提物和苞葉雪蓮水提物,灌胃14 d後接受4 Gy的X線一次性全身照射,24 h後處死小鼠,測量小鼠骨髓細胞微覈率.結果 山楂組和苞葉雪蓮組微覈率均低于造模組,差異均有統計學意義,P<0.05.結論 山楂及苞葉雪蓮水提物中的活性成分對小鼠有一定程度的防輻射損傷作用.
목적 연구산사화포협설련수제물대소서적방복사작용.방법 선택40지소서작위연구대상,수궤분배도공백조、조모조、산사조、포협설련진행실험,조모조、산사조、포협설련분별급이상동제량적0.9%생리염수、산사수제물화포협설련수제물,관위14 d후접수4 Gy적X선일차성전신조사,24 h후처사소서,측량소서골수세포미핵솔.결과 산사조화포협설련조미핵솔균저우조모조,차이균유통계학의의,P<0.05.결론 산사급포협설련수제물중적활성성분대소서유일정정도적방복사손상작용.
Objective To preliminarily explore the radioprotective effects of the aqueous extract of Crataegusand Saussurea obvallata on the mice from radiation injury.Methods After mice were irradiated with 4 Gy of X-ray, administered at same doses of aqueous extract of Crataegusand Saussurea obvallata for 14 days. 1 days after irradiation, mice were sacrificed and measured micronucleus rate.Results Each treatment group with irradiation group compared with the irradiated group, Crataegus dose and Saussurea obvallata dose mice micronucleu rate was lower than the model group, which in the dose group and Crataegus dose group was significantly lower than the model group, there was significant difference,P<0.01.Conclusions The natural herb Crataegusand Saussurea obvallata active ingredient have some degree of radioprotective effects in mice, which Crataegus dose group was significantly more than Saussurea obvallata dose.
