国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
Journal Of International Obstetrics And Gynecology
2015年
5期
560-563
,共4页
卵巢肿瘤%肿瘤标记,生物学%CA-125抗原%附睾分泌蛋白质类%骨桥蛋白质
卵巢腫瘤%腫瘤標記,生物學%CA-125抗原%附睪分泌蛋白質類%骨橋蛋白質
란소종류%종류표기,생물학%CA-125항원%부고분비단백질류%골교단백질
Ovarian neoplasms%Tumor markers,biological%CA-125 antigen%Epididymal secretory proteins%Osteopontin
卵巢癌是女性生殖系统中病死率最高的恶性肿瘤，由于缺乏早期有效的筛查手段，多数患者确诊时已为晚期，治愈率只有20%～30%，而早期患者的生存率较晚期患者高。因此，提高卵巢癌的早期诊断是改善患者生存质量的重要且有效的途径。目前临床上主要的筛查手段是经阴道超声检查联合血清肿瘤标记物的检测。除了糖类抗原125（CA125）广泛用于卵巢癌的诊断、检测和预后评估外，人附睾蛋白4（HE4）、骨桥蛋白（OPN）、间皮素（MSLN）和协同刺激分子B7-H4等生物学标记物也开始成为卵巢癌诊断的辅助或补充手段，以提高卵巢癌的早期检出率和诊断准确性。其中，OPN和B7-H4可作为卵巢癌诊断和靶基因治疗的理想指标和目的基因。检测患者尿液中可溶性MSLN相关蛋白（SMRP）和OPN的含量为卵巢癌的诊断提供了非侵袭性的方法。简要综述目前研究发现的与卵巢癌相关的血清学标记物。
卵巢癌是女性生殖繫統中病死率最高的噁性腫瘤，由于缺乏早期有效的篩查手段，多數患者確診時已為晚期，治愈率隻有20%～30%，而早期患者的生存率較晚期患者高。因此，提高卵巢癌的早期診斷是改善患者生存質量的重要且有效的途徑。目前臨床上主要的篩查手段是經陰道超聲檢查聯閤血清腫瘤標記物的檢測。除瞭糖類抗原125（CA125）廣汎用于卵巢癌的診斷、檢測和預後評估外，人附睪蛋白4（HE4）、骨橋蛋白（OPN）、間皮素（MSLN）和協同刺激分子B7-H4等生物學標記物也開始成為卵巢癌診斷的輔助或補充手段，以提高卵巢癌的早期檢齣率和診斷準確性。其中，OPN和B7-H4可作為卵巢癌診斷和靶基因治療的理想指標和目的基因。檢測患者尿液中可溶性MSLN相關蛋白（SMRP）和OPN的含量為卵巢癌的診斷提供瞭非侵襲性的方法。簡要綜述目前研究髮現的與卵巢癌相關的血清學標記物。
란소암시녀성생식계통중병사솔최고적악성종류，유우결핍조기유효적사사수단，다수환자학진시이위만기，치유솔지유20%～30%，이조기환자적생존솔교만기환자고。인차，제고란소암적조기진단시개선환자생존질량적중요차유효적도경。목전림상상주요적사사수단시경음도초성검사연합혈청종류표기물적검측。제료당류항원125（CA125）엄범용우란소암적진단、검측화예후평고외，인부고단백4（HE4）、골교단백（OPN）、간피소（MSLN）화협동자격분자B7-H4등생물학표기물야개시성위란소암진단적보조혹보충수단，이제고란소암적조기검출솔화진단준학성。기중，OPN화B7-H4가작위란소암진단화파기인치료적이상지표화목적기인。검측환자뇨액중가용성MSLN상관단백（SMRP）화OPN적함량위란소암적진단제공료비침습성적방법。간요종술목전연구발현적여란소암상관적혈청학표기물。
Ovarian cancer is the most leading cause of death in gynecologic malignancies. Since lack of early detection strategies, the majority of the patients are diagnosed at advanced stage disease, of which the cure rate is only 20%-30%. It has been observed that the survival rate of patients at early stages is higher than those diagnosed with advanced disease. Therefore, to improve the quality of patients′life, it is important and effective to get the early diagnosis methods of ovarian cancer. At present, transvaginal ultrasound combining with detection of serum tumor markers is the main clinical screening strategy. In order to improve the accuracy of early detection and diagnosis of ovarian cancer, in addition to carbohydrate antigen 125 (CA125), which is widely used to diagnosis of ovarian carcinoma, monitor its development and evaluate the prognosis, human epididymis protein 4 (HE4), osteopontin (OPN), mesothelin (MSLN) and costimulatory molecules B7-H4 also begin to become supplementary means for diagnosis of ovarian carcinoma. Then, OPN and B7-H4 can be used as ideal target genes and purpose for diagnosis of ovarian cancer. Detection of soluble mesothelin-related protein (SMRP) and OPN in patients′urine is a noninvasive method of diagnosis of ovarian cancer. This paper reviews the serologic tumor markers associated with ovarian cancer that had been verified at present.
