CAJ | 학술논문

尽管早期子宫内膜癌预后良好，部分患者术后仍可能复发或转移。根据复发高危因素选择理想的术后辅助治疗，是目前临床上亟需解决的问题。对1990—2013年公开发表的Ⅲ期临床试验进行总结，评价各种辅助治疗在早期子宫内膜癌中的作用。对低危复发风险者，术后观察是适合的；对于中危复发风险者，阴道近距离照射也许是更好的选择；而对于高危复发风险者，盆腔外照射控制复发及改善生存率的效果还不理想，化疗在这一类患者中的作用尚在研究中。
진관조기자궁내막암예후량호，부분환자술후잉가능복발혹전이。근거복발고위인소선택이상적술후보조치료，시목전림상상극수해결적문제。대1990—2013년공개발표적Ⅲ기림상시험진행총결，평개각충보조치료재조기자궁내막암중적작용。대저위복발풍험자，술후관찰시괄합적；대우중위복발풍험자，음도근거리조사야허시경호적선택；이대우고위복발풍험자，분강외조사공제복발급개선생존솔적효과환불이상，화료재저일류환자중적작용상재연구중。
Despite the good prognosis of early stage endometrial cancer, a part of patients will experience localized disease relapse or distant metastasis following surgery. It is to be solved that how to choose the ideal adjuvant therapy according to the high risk factors. This article conducted a review forⅢphase clinical trials on record during 1990—2013, to evaluate the efficacy and safety of different adjuvant therapies in patient with early stage endometrial cancer. Post-surgical observation is appropriate for low risk patients; brachytherapy may be a better choice for intermediate risk patients; while for high risk patients, external beam radiotherapy is not effective enough in local relapse control and survival rate improvement, and the efficacy of adjuvant chemotherapy is still in study.