CAJ | 학술논문

目的：探讨监测血清人附睾蛋白4（HE4）、糖类抗原125（CA125）水平变化在卵巢癌术后疗效评估中的应用价值。方法：应用电化学发光法随访34例上皮性卵巢癌（epithelial ovarian cancer，EOC）患者手术后1周、1个月、3个月、6个月HE4、CA125水平，并与手术前进行比较，同时将术后病情发展情况与对应的HE4、CA125水平变化进行比较。结果：EOC患者术前血清的HE4、CA125水平均高于健康对照组（P＜0.01）；手术后病情缓解患者27例，其术后1周、1个月、3个月、6个月的HE4、CA125水平均低于术前，差异有统计学意义（P＜0.01）；随着术后时间的延长，HE4、CA125水平不断降低，差异有统计学意义（P＜0.0125）；术后病情继续进展患者7例，其HE4和CA125水平术后1周和术后1个月降低，差异有统计学意义（P＜0.05）；联合HE4和CA125水平与手术后EOC病情发展趋势符合率为85.3%。结论：联合检测HE4和CA125对EOC手术后疗效评估、监测病情发展有重要临床价值。
목적：탐토감측혈청인부고단백4（HE4）、당류항원125（CA125）수평변화재란소암술후료효평고중적응용개치。방법：응용전화학발광법수방34례상피성란소암（epithelial ovarian cancer，EOC）환자수술후1주、1개월、3개월、6개월HE4、CA125수평，병여수술전진행비교，동시장술후병정발전정황여대응적HE4、CA125수평변화진행비교。결과：EOC환자술전혈청적HE4、CA125수평균고우건강대조조（P＜0.01）；수술후병정완해환자27례，기술후1주、1개월、3개월、6개월적HE4、CA125수평균저우술전，차이유통계학의의（P＜0.01）；수착술후시간적연장，HE4、CA125수평불단강저，차이유통계학의의（P＜0.0125）；술후병정계속진전환자7례，기HE4화CA125수평술후1주화술후1개월강저，차이유통계학의의（P＜0.05）；연합HE4화CA125수평여수술후EOC병정발전추세부합솔위85.3%。결론：연합검측HE4화CA125대EOC수술후료효평고、감측병정발전유중요림상개치。
Objective:To explore the application value of serum HE4 and CA125 level changes in the assessment of curative effect in ovarian cancer. Methods:HE4 and CA125 levels of 34 patients suffering from epithelial ovarian cancer (EOC) were measured by electrochemiluminescence in one week ,one month, three months and six months after surgery and compared with the corresponding values before surgery. The relevance between disease progression after surgery and the corresponding changes of HE4 and CA125 levels was compared. Results:HE4 and CA125 levels in serum of EOC patients were significantly higher than the control group (P<0.01). In 27 remission cases, HE4 and CA125 values in one week, one month, three months and six months after surgery were significantly lower than before surgery (P<0.01). The concentration of two markers were decreasing as the extension of time after surgery (P<0.012 5). HE4 and CA125 levels showed statistical difference in 7 postoperative deterioration cases in one week and one month after the surgery (P<0.05). Joint detection of HE4 and CA125 can elevate the coincidence rate to 85.3%. Conclusions:Simultaneous detection of HE4 and CA125 may have important value of clinical efficacy evaluation and monitoring of disease after EOC surgery.