CAJ | 학술논문

巨噬细胞移动抑制因子（MIF）是近年研究非常广泛的细胞因子之一。生理情况下，MIF可以介导炎症及免疫反应，参与胚胎期的发育、组织创伤后的修复等。MIF还被证实在妇科恶性肿瘤，如宫颈癌、卵巢癌、子宫内膜癌等的发展过程中发挥重要作用，并与肿瘤的恶性程度密切相关。MIF可以激活多种信号通路，如c-Jun氨基末端激酶（JNK/c-Jun）、磷脂酰肌醇3激酶/蛋白激酶B（PI3K/Akt）等，通过促进细胞增殖、黏附、转移、血管新生、上皮间质转化和增强免疫抑制等方式加速肿瘤的发展。此外，许多研究都显示，抑制MIF的分泌及生物学活性可以有效减慢，甚至逆转肿瘤的发展，有效的MIF抑制剂有望成为治疗癌症的新希望。
거서세포이동억제인자（MIF）시근년연구비상엄범적세포인자지일。생리정황하，MIF가이개도염증급면역반응，삼여배태기적발육、조직창상후적수복등。MIF환피증실재부과악성종류，여궁경암、란소암、자궁내막암등적발전과정중발휘중요작용，병여종류적악성정도밀절상관。MIF가이격활다충신호통로，여c-Jun안기말단격매（JNK/c-Jun）、린지선기순3격매/단백격매B（PI3K/Akt）등，통과촉진세포증식、점부、전이、혈관신생、상피간질전화화증강면역억제등방식가속종류적발전。차외，허다연구도현시，억제MIF적분비급생물학활성가이유효감만，심지역전종류적발전，유효적MIF억제제유망성위치료암증적신희망。
Macrophage migration inhibitory factor (MIF) is one of the most widely researched cytokines in recent years. Under physiological conditions, MIF mediates inflammation and immune response in embryonic development, tissues repair after trauma. Recently, MIF has also been proved to play a pivotal role during the development of gynecologic malignant tumors, such as cervical cancer, ovarian cancer, endometrial cancer and so on, and it also has a close relationship with the malignant degree of tumors. MIF can activate a variety of signaling pathways, such as JNK/c-Jun and PI3K/Akt. MIF can accelerate the progression of malignant tumors through promoting cells proliferation, adhesion, metastasis, angiogenesis, immune suppression and so on. Studies have shown that inhibition of secretion and biological activity of MIF can effectively slow down or even reverse tumor development. MIF antagonist may be a new therapeutic target for tumors.