广东医学
廣東醫學
엄동의학
Guangdong Medical Journal
2015年
18期
2797-2799
,共3页
刘悟%谭小青%刘翠中%阳军
劉悟%譚小青%劉翠中%暘軍
류오%담소청%류취중%양군
冠心病%前蛋白转化酶枯草溶菌素9%冠状动脉病变
冠心病%前蛋白轉化酶枯草溶菌素9%冠狀動脈病變
관심병%전단백전화매고초용균소9%관상동맥병변
coronary heart disease%PCSK9%coronary lesions
目的 探讨血清前蛋白转化酶枯草溶菌素9(PCSK9)与冠心病影响因素及冠状动脉病变程度的相关性. 方法 使用双抗夹心ELISA法检测行冠状动脉造影检查的176例患者的血清PCSK9水平,根据冠状动脉造影结果分为冠心病组(冠状动脉狭窄≥50%) 116例和对照组(冠状动脉狭窄<50%) 60例,冠心病组根据冠状动脉病变范围分为单支病变组42例、双支病变组36例、三支病变组38例. 使用Gensini评分系统对冠状动脉病变程度进行评估,并对冠心病组患者的血清PCSK9与Gensini评分及冠心病各影响因素进行相关分析. 结果 冠心病组血清PCSK9水平明显高于对照组( P<0.05 );冠心病组血清PCSK9 水平与Gensini评分呈正相关( P<0.05);冠心病组各亚组血清PCSK9水平比较,三支病变组>双支病变组>单支病变组(P<0.05);血清PCSK9水平与年龄、收缩压、空腹血糖、低密度脂蛋白胆固醇、三酰甘油、总胆固醇等呈正相关( P<0.05 ). 结论 冠心病人群中血清PCSK9水平与冠心病影响因素、冠状动脉病变程度密切相关.
目的 探討血清前蛋白轉化酶枯草溶菌素9(PCSK9)與冠心病影響因素及冠狀動脈病變程度的相關性. 方法 使用雙抗夾心ELISA法檢測行冠狀動脈造影檢查的176例患者的血清PCSK9水平,根據冠狀動脈造影結果分為冠心病組(冠狀動脈狹窄≥50%) 116例和對照組(冠狀動脈狹窄<50%) 60例,冠心病組根據冠狀動脈病變範圍分為單支病變組42例、雙支病變組36例、三支病變組38例. 使用Gensini評分繫統對冠狀動脈病變程度進行評估,併對冠心病組患者的血清PCSK9與Gensini評分及冠心病各影響因素進行相關分析. 結果 冠心病組血清PCSK9水平明顯高于對照組( P<0.05 );冠心病組血清PCSK9 水平與Gensini評分呈正相關( P<0.05);冠心病組各亞組血清PCSK9水平比較,三支病變組>雙支病變組>單支病變組(P<0.05);血清PCSK9水平與年齡、收縮壓、空腹血糖、低密度脂蛋白膽固醇、三酰甘油、總膽固醇等呈正相關( P<0.05 ). 結論 冠心病人群中血清PCSK9水平與冠心病影響因素、冠狀動脈病變程度密切相關.
목적 탐토혈청전단백전화매고초용균소9(PCSK9)여관심병영향인소급관상동맥병변정도적상관성. 방법 사용쌍항협심ELISA법검측행관상동맥조영검사적176례환자적혈청PCSK9수평,근거관상동맥조영결과분위관심병조(관상동맥협착≥50%) 116례화대조조(관상동맥협착<50%) 60례,관심병조근거관상동맥병변범위분위단지병변조42례、쌍지병변조36례、삼지병변조38례. 사용Gensini평분계통대관상동맥병변정도진행평고,병대관심병조환자적혈청PCSK9여Gensini평분급관심병각영향인소진행상관분석. 결과 관심병조혈청PCSK9수평명현고우대조조( P<0.05 );관심병조혈청PCSK9 수평여Gensini평분정정상관( P<0.05);관심병조각아조혈청PCSK9수평비교,삼지병변조>쌍지병변조>단지병변조(P<0.05);혈청PCSK9수평여년령、수축압、공복혈당、저밀도지단백담고순、삼선감유、총담고순등정정상관( P<0.05 ). 결론 관심병인군중혈청PCSK9수평여관심병영향인소、관상동맥병변정도밀절상관.
Objective To investigate the correlation of serum PCSK9 levels with influence factors of coronary heart disease ( CHD) and severity of coronary artery lesions.Methods ELISA was used to detected serum PCSK9 in 176 patients who underwent coronary angiography examination.According to the result of coronary angiography examina-tion, patients were divided into the control group of 60 cases and the CHD group of 116 cases.According to the range of coronary artery lesions, the CHD group was further divided into the single-vessel group of 42 cases, the double-vessel group of 36 cases and the triple-vessels group of 38 cases.The severity of coronary lesions was evaluated with the Gensini system.Correlation analysis was applied regarding PCSK9, Gensini score and CHD influence factors in the CHD group. Results Serum PCSK9 level in the CHD group was higher than that in the control group ( P<0.05) .The Gensini score was positively correlated with serum PCSK9 in the CHD group (P<0.05).Serum PCSK9 level of the triple-vessel group was higher than of that the double vessels group, which was even higher than that of the single-vessel group (P<0.05). In addition, serum PCSK9 were positively correlated with influence factors of CHD, e.g.age, systolic blood pressure, fasting blood glucose, low density lipoprotein, triglyceride and total cholesterol (P<0.05).Conclusion Serum PCSK9 levels were closely associated with influence factors of CHD and severity of coronary lesions in the CHD population.
