中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
27期
5-7
,共3页
甲状腺抗体%复发性流产%相关性
甲狀腺抗體%複髮性流產%相關性
갑상선항체%복발성유산%상관성
Thyroid antibody%Recurrent spontaneous abortion%Correlation
目的 探讨甲状腺抗体阳性对复发性流产的影响. 方法 整群选取在2011年5月-2014年5月期间该院收治的有自然流产史但处于非孕期的妇女103例为观察组,在同一时间段内选取有正常分娩史的非孕期妇女 97例为对照组,用化学发光法检测两组妇女血清中甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb),研究甲状腺抗体阳性对复发性流产的影响. 结果 观察组妇女血清中甲状腺自身抗体 (TA) 总阳性率21.36%、TgAb阳性率15.53%和TPOAb阳性率17.48%均高于对照组10.31%、5.15%、6.19%,差异有统计学意义(P<0.05). 观察组妇女血清中TgAb定量值(1.34±0.39)稍高于对照组(1.28±0.27),差异无统计学意义(P>0.05);而观察组妇女血清中TPOAb定量值(0.94±0.41)高于对照组(0.73±0.26),差异有统计学意义(P<0.05). TA阳性、TgAb阳性和TPOAb阳性3个变量中,仅有TPOAb阳性保留到最后,且观察组妇女TPOAb阳性比例是对照组的3.51倍. 结论 甲状腺抗体与复发性流产之间具有相关性,复发性自然流产妇女的甲状腺抗体阳性率增高,在临床上值得借鉴,对预防和治疗复发性流产的发生有重要意义.
目的 探討甲狀腺抗體暘性對複髮性流產的影響. 方法 整群選取在2011年5月-2014年5月期間該院收治的有自然流產史但處于非孕期的婦女103例為觀察組,在同一時間段內選取有正常分娩史的非孕期婦女 97例為對照組,用化學髮光法檢測兩組婦女血清中甲狀腺毬蛋白抗體(TgAb)和甲狀腺過氧化物酶抗體(TPOAb),研究甲狀腺抗體暘性對複髮性流產的影響. 結果 觀察組婦女血清中甲狀腺自身抗體 (TA) 總暘性率21.36%、TgAb暘性率15.53%和TPOAb暘性率17.48%均高于對照組10.31%、5.15%、6.19%,差異有統計學意義(P<0.05). 觀察組婦女血清中TgAb定量值(1.34±0.39)稍高于對照組(1.28±0.27),差異無統計學意義(P>0.05);而觀察組婦女血清中TPOAb定量值(0.94±0.41)高于對照組(0.73±0.26),差異有統計學意義(P<0.05). TA暘性、TgAb暘性和TPOAb暘性3箇變量中,僅有TPOAb暘性保留到最後,且觀察組婦女TPOAb暘性比例是對照組的3.51倍. 結論 甲狀腺抗體與複髮性流產之間具有相關性,複髮性自然流產婦女的甲狀腺抗體暘性率增高,在臨床上值得藉鑒,對預防和治療複髮性流產的髮生有重要意義.
목적 탐토갑상선항체양성대복발성유산적영향. 방법 정군선취재2011년5월-2014년5월기간해원수치적유자연유산사단처우비잉기적부녀103례위관찰조,재동일시간단내선취유정상분면사적비잉기부녀 97례위대조조,용화학발광법검측량조부녀혈청중갑상선구단백항체(TgAb)화갑상선과양화물매항체(TPOAb),연구갑상선항체양성대복발성유산적영향. 결과 관찰조부녀혈청중갑상선자신항체 (TA) 총양성솔21.36%、TgAb양성솔15.53%화TPOAb양성솔17.48%균고우대조조10.31%、5.15%、6.19%,차이유통계학의의(P<0.05). 관찰조부녀혈청중TgAb정량치(1.34±0.39)초고우대조조(1.28±0.27),차이무통계학의의(P>0.05);이관찰조부녀혈청중TPOAb정량치(0.94±0.41)고우대조조(0.73±0.26),차이유통계학의의(P<0.05). TA양성、TgAb양성화TPOAb양성3개변량중,부유TPOAb양성보류도최후,차관찰조부녀TPOAb양성비례시대조조적3.51배. 결론 갑상선항체여복발성유산지간구유상관성,복발성자연유산부녀적갑상선항체양성솔증고,재림상상치득차감,대예방화치료복발성유산적발생유중요의의.
Objective To investigate the effect of positive thyroid antibody on recurrent spontaneous abortion. Methods 103 non-pregnant women with the history of spontaneous abortion and 97 non-pregnant women with the history of normal delivery admitted in our hospital from May 2011 to May 2014 were selected as the observation group and the control group, respectively. Chemilu-minescence method was used to test the thyroglobulin antibody (TgAb) and thyroid peroxidase antibody (TPOAb) in both groups. And the effect of positive thyroid antibody on recurrent spontaneous abortion was studied. Results Compared with the control group, the observation group had much higher total positive rate of serum thyroid autoantibody (TA)(21.36%vs 10.31%), obviously higher positive rate of serum TgAb(15.53% vs 5.15%), significantly higher positive rate of serum TPOAb (17.48% vs 6.19%) (P<0.05). The serum quantitative value of TgAb was slightly higher in the observation group than that in the control group[(1.34 ±0.39) vs (1.28±0.27)] (P>0.05). The serum quantitative value of TPOAb was much higher in the observation group than that in the control group [(0.94±0.41) vs (0.73±0.26)] (P<0.05). The three variables, positive TA, positive TgAb and positive TPOAb, only positive TPOAb until the end, and the TPOAb positive ratio in the observation group was 3.51 times higher than that in the control group. Conclusion Thyroid antibody has correlation with recurrent spontaneous abortion. The positive rate of thyroid antibody increases significantly in women with recurrent spontaneous abortion, which is worthy of clinical reference in the prevention and treatment of recurrent spontaneous abortion.
