辽宁医学院学报
遼寧醫學院學報
료녕의학원학보
Journal of Liaoning Medical University
2015年
5期
1-4
,共4页
路楠%田晶晶%胜芙蓉%陈一波%赵宏丽
路楠%田晶晶%勝芙蓉%陳一波%趙宏麗
로남%전정정%성부용%진일파%조굉려
愈创木酚甘油醚%缓释片%释放度
愈創木酚甘油醚%緩釋片%釋放度
유창목분감유미%완석편%석방도
guaifenesin%sustained-release tablets%release
目的 研制愈创木酚甘油醚缓释片, 并考察其体外释放度. 方法 以愈创木酚甘油醚为模型药物, HPMC为骨架材料, 通过正交试验优选处方; 以水为释放介质, 采用紫外分光光度法, 考察愈创木酚甘油醚缓释片的体外释放度. 结果 缓释片处方为: 愈创木酚甘油醚40 g, HPMC 11 g, 微晶纤维素15 g, 聚维酮乙醇浓度为20%, 硬脂酸镁1%; 药物含量和体外释放度均符合规定. 结论 本品处方和工艺设计合理, 样品释放度12 h累积释放率达到了90%以上, 符合缓释片的释药要求.
目的 研製愈創木酚甘油醚緩釋片, 併攷察其體外釋放度. 方法 以愈創木酚甘油醚為模型藥物, HPMC為骨架材料, 通過正交試驗優選處方; 以水為釋放介質, 採用紫外分光光度法, 攷察愈創木酚甘油醚緩釋片的體外釋放度. 結果 緩釋片處方為: 愈創木酚甘油醚40 g, HPMC 11 g, 微晶纖維素15 g, 聚維酮乙醇濃度為20%, 硬脂痠鎂1%; 藥物含量和體外釋放度均符閤規定. 結論 本品處方和工藝設計閤理, 樣品釋放度12 h纍積釋放率達到瞭90%以上, 符閤緩釋片的釋藥要求.
목적 연제유창목분감유미완석편, 병고찰기체외석방도. 방법 이유창목분감유미위모형약물, HPMC위골가재료, 통과정교시험우선처방; 이수위석방개질, 채용자외분광광도법, 고찰유창목분감유미완석편적체외석방도. 결과 완석편처방위: 유창목분감유미40 g, HPMC 11 g, 미정섬유소15 g, 취유동을순농도위20%, 경지산미1%; 약물함량화체외석방도균부합규정. 결론 본품처방화공예설계합리, 양품석방도12 h루적석방솔체도료90%이상, 부합완석편적석약요구.
Objective To prepare the guaifenesin sustained-release tablets, and evaluate its release in vitro. Methods The prescription was optimized by orthogonal experiment with guaifenesin as model drug and HPMC as the skeleton material. The in-vitro release of guaifenesin sustained-release tablets was observed and analyzed by ultraviolet spectrophotometry with water as medium. Re-sults The prescription included 40 g guaifenesin, 11 g HPMC, 15 g microcrystalline cellulose, 20% povidone-ethanol solution and 1% magnesium stearate. The content and release in vitro were both up to standard. Conclusion This prescription and craft design are reasonable, and the release in vitro is accorded with the requirement of 90% cumulative release of sustained-release tablets in 12 hours.
