CAJ | 학술논문

目的：探讨血清超敏C-反应蛋白（hs-CRP）与颈动脉粥样硬化及急性脑梗死的相关性。方法选取我院2012年3月～2015年4月住院的206例急性脑梗死患者与90例同期健康体检者进行血清hs-CRP水平测定、颈动脉彩色多普勒超声检查，比较2组患者hs-CRP含量变化、并分析急性脑梗死患者hs-CRP与颈动脉粥样硬化的关系。结果急性脑梗死组血清hs-CRP含量高于正常对照组（P＜0.01），不同病情程度急性脑梗死患者hs-CRP水平呈现重型＞中型＞轻型的趋势，差异有统计学意义（P ＜0.05或P ＜0.01）；不稳定斑块组血清hs-CRP 水平高于稳定性斑块组，差异有统计学意义（P ＜0.01）。结论血清hs-CRP 与急性脑梗死的发生、病情严重程度有关，与神经功能缺损程度呈正相关，可以作为预测脑梗死发展和预后的指标；hs- CRP 与颈动脉粥样硬化形成及斑块活动性密切相关，可作为风险标志物。
목적：탐토혈청초민C-반응단백（hs-CRP）여경동맥죽양경화급급성뇌경사적상관성。방법선취아원2012년3월～2015년4월주원적206례급성뇌경사환자여90례동기건강체검자진행혈청hs-CRP수평측정、경동맥채색다보륵초성검사，비교2조환자hs-CRP함량변화、병분석급성뇌경사환자hs-CRP여경동맥죽양경화적관계。결과급성뇌경사조혈청hs-CRP함량고우정상대조조（P＜0.01），불동병정정도급성뇌경사환자hs-CRP수평정현중형＞중형＞경형적추세，차이유통계학의의（P ＜0.05혹P ＜0.01）；불은정반괴조혈청hs-CRP 수평고우은정성반괴조，차이유통계학의의（P ＜0.01）。결론혈청hs-CRP 여급성뇌경사적발생、병정엄중정도유관，여신경공능결손정도정정상관，가이작위예측뇌경사발전화예후적지표；hs- CRP 여경동맥죽양경화형성급반괴활동성밀절상관，가작위풍험표지물。
Objective The aim of this study was to investigate the relationship between serum high sensitivity C-reactive protein (hs-CRP) levels with carotid atherosclerosis and acute cerebral infarction. MethodsThis is a cross-sectional study, which were included 206 hospitalized patients with acute cerebral infarction and 90 healthy control cases by physical examination from March 2012 to April 2015. Each subject underwent carotid artery color Doppler ultrasonic examination. Serum hs-CRP was measured using immune turbidity method. Chi square test were used to analyze relations between serum hs-CRP levels with carotid atherosclerosis.ResultsThe serum levels of hs-CRP in acute cerebral infarction group were significantly higher than in control group (P<0.01), and hs-CRP levels relations with different severity of degree of acute cerebral infarction showed a trend of heavy, medium and light. (P<0.05 orP<0.01), and serum levels of hs-CRP in unstable plaque group was signiifcantly higher than that in the stable plaque group (P<0.01).Conclusion The serum levels of hs-CRP were associated with the occurrence and severity of acute cerebral infarction, were positively correlated the degree of nerve function defect, which can be used as a prospective biomarker of cerebral infarction development and prognosis. The hs-CRP also can be a risk marker of carotid atherosclerosis which was closely related to the plaque formation and activity.