医药导报
醫藥導報
의약도보
Herald of Medicine
2015年
11期
1501-1505
,共5页
胡俊杰%张宝徽%吕秋霞%王桂红%郑国华
鬍俊傑%張寶徽%呂鞦霞%王桂紅%鄭國華
호준걸%장보휘%려추하%왕계홍%정국화
黄地巴布剂%黄芪甲苷%龙血素B%色谱法,薄层%色谱法,高效液相%质量标准
黃地巴佈劑%黃芪甲苷%龍血素B%色譜法,薄層%色譜法,高效液相%質量標準
황지파포제%황기갑감%룡혈소B%색보법,박층%색보법,고효액상%질량표준
Huangdi cataplasm%Astragaloside A%Loureirin B%Chromatography,thin ̄layer%Chromatography,high performance liquid%Quality standard
目的:建立黄地巴布剂的质量标准。方法采用薄层色谱法对巴布剂中所含黄芪、大黄、川芎、当归、龙血竭等进行定性鉴别,采用高效液相色谱法对制剂中的黄芪甲苷和龙血素 B 进行含量测定。结果薄层色谱法能定性检出黄芪、大黄、川芎、当归、龙血竭,斑点清晰,分离度好,且阴性对照无干扰;黄芪甲苷和龙血素 B 进样量分别在6.96~23.2,0.072~0.648μg 范围内与峰面积呈现良好的线性关系,r =0.9995,0.9999;平均回收率为97.18%,96.93%,RSD 为1.21%(n=6),1.53%(n=6)。结论所建立的定性、定量检测方法操作简便,专属性强,重复性好,结果准确可靠,可作为黄地巴布剂的质量控制方法。
目的:建立黃地巴佈劑的質量標準。方法採用薄層色譜法對巴佈劑中所含黃芪、大黃、川芎、噹歸、龍血竭等進行定性鑒彆,採用高效液相色譜法對製劑中的黃芪甲苷和龍血素 B 進行含量測定。結果薄層色譜法能定性檢齣黃芪、大黃、川芎、噹歸、龍血竭,斑點清晰,分離度好,且陰性對照無榦擾;黃芪甲苷和龍血素 B 進樣量分彆在6.96~23.2,0.072~0.648μg 範圍內與峰麵積呈現良好的線性關繫,r =0.9995,0.9999;平均迴收率為97.18%,96.93%,RSD 為1.21%(n=6),1.53%(n=6)。結論所建立的定性、定量檢測方法操作簡便,專屬性彊,重複性好,結果準確可靠,可作為黃地巴佈劑的質量控製方法。
목적:건립황지파포제적질량표준。방법채용박층색보법대파포제중소함황기、대황、천궁、당귀、룡혈갈등진행정성감별,채용고효액상색보법대제제중적황기갑감화룡혈소 B 진행함량측정。결과박층색보법능정성검출황기、대황、천궁、당귀、룡혈갈,반점청석,분리도호,차음성대조무간우;황기갑감화룡혈소 B 진양량분별재6.96~23.2,0.072~0.648μg 범위내여봉면적정현량호적선성관계,r =0.9995,0.9999;평균회수솔위97.18%,96.93%,RSD 위1.21%(n=6),1.53%(n=6)。결론소건립적정성、정량검측방법조작간편,전속성강,중복성호,결과준학가고,가작위황지파포제적질량공제방법。
Objective To develop the quality standard for evaluating Huangdi cataplasm. Methods Thin layer chromatography (TLC) was used to qualitatively identify Astragalus membranaceus (Fisch.) Bunge,Rheum palmatum Linn,Rhizoma Chuanxiong,Angelica sinensis and Resina Draconis in Huangdi cataplasm.HPLC method was used to determine astragaloside A and loureirin B in Huangdi cataplasm. Results The Astragalus membranaceus (Fisch.) Bunge,Rheum palmatum Linn,Rhizoma Chuanxiong,Angelica sinensis and Resina Draconis were well separated by TLC without interference in the negative control.content of Astragaloside A and loureirin B showed good liner relationships with respective peak area within the range of 6.96-23.2 μg,and 0.072-0.648 μg,with r = 0.999 5,r = 0.999 9, respectively;and the average recovery was 97.18%,and 96.93%,RSD was 1.21%(n= 6),1.53% (n = 6 ), respectively. Conclusion The established qualitative and quantitative detection method is simple, specific, reproducible, accurate and reliable, which can be used for quality control of Huangdi cataplasm.