CAJ | 학술논문

目的：探讨抗菌药物合理应用对医院感染病原菌耐药性的影响。方法选取我院2012年1月～2013年12月诊治感染的患者1020例患者为对照组，另选取我院2013年1月～2013年12月诊治感染的1354例患者为观察组，观察组采用联动监管的方式对抗菌药物的应用进行合理管理。结果观察组耐药菌检出率及抗菌药物使用强度均低于对照组，两组患者革兰阴性菌、革兰阳性菌、真菌分布存在明显差异（P＜0.05）；观察组真菌分布低于对照组，非发酵菌分布高于对照组，差异有统计学意义（P＜0.05）。结论联动监管抗菌药物应用的方式，能够有效促进抗菌药物合理应用，降低病原菌耐药性的发生率，改善病原菌耐药性分布。
목적：탐토항균약물합리응용대의원감염병원균내약성적영향。방법선취아원2012년1월～2013년12월진치감염적환자1020례환자위대조조，령선취아원2013년1월～2013년12월진치감염적1354례환자위관찰조，관찰조채용련동감관적방식대항균약물적응용진행합리관리。결과관찰조내약균검출솔급항균약물사용강도균저우대조조，량조환자혁란음성균、혁란양성균、진균분포존재명현차이（P＜0.05）；관찰조진균분포저우대조조，비발효균분포고우대조조，차이유통계학의의（P＜0.05）。결론련동감관항균약물응용적방식，능구유효촉진항균약물합리응용，강저병원균내약성적발생솔，개선병원균내약성분포。
Objective To explore the impact of the rational use of antibiotics on pathogen resistance in nosocomial infection.Methods 1 020 cases of infection patients from January 2012 to December 2013 were selected as control group, other 1 354 cases of infection patients from January 2013 to December 2013 were selected as observation group which used linkage supervision to administer antimicrobial drugs.Results The detection rate of drug-resistant bacteria and antibacterial drug use intensity of observation group were signiifcantly lower than control group (P<0.05), distribution of Gram-negative bacteria, Gram-positive bacteria and fungus of two groups were significantly different (P<0.05).Conclusion The use of antibiotics linkage supervision can effectively promote rational use of antibiotics, reduce the incidence of pathogen resistance, and improve the distribution of pathogens resistant.