中国继续医学教育
中國繼續醫學教育
중국계속의학교육
China Continuing Medical Education
2015年
28期
35-36,37
,共3页
早发型重度子痫前期%血清25-OH-VitD%子宫动脉PI值
早髮型重度子癇前期%血清25-OH-VitD%子宮動脈PI值
조발형중도자간전기%혈청25-OH-VitD%자궁동맥PI치
25-OH-VitD%Onset early severe preeclampsia%Uterine artery Doppler pulsatility index
目的：研究早孕期血清25-OH-VitD水平与子宫动脉PI联合检测对早发型重度子痫前期（EOSP）的预测价值。方法选择2013年1月～2015年1月在我院门诊早孕期建卡的初次单胎妊娠无合并症的妇女5000例作为研究对象，孕周为8～13周+6天，用化学发光法进行血清维生素D(25-OH-VitD)水平检测，并记录入选者在孕11～13周+6天测NT时行双侧子宫动脉PI值的测定。共有1748例孕妇完成研究，规律产检并在我院分娩。实验分组：A组维生素D水平正常+PI＜2.4；B组维生素D水平缺乏+PI＜2.4；C组维生素D水平正常+PI＞2.4；D组；维生素D水平缺乏+PI＞2.4；比较4组EOSP发病率。结果 EOSP患者早孕期血清维生素D缺乏者为96%，低于正常孕妇，而PI值高于正常组，P＜0.05。EOSP发病率D组最高， A组最低，均与其它三组差异明显，P＜0.05。B与C组无明显差异。结论早孕期维生素D缺乏可能是EOSP发病的独立危险因素。早孕期血清维生素D与子宫动脉PI联合检测对EOSP发病有较好的预测价值。
目的：研究早孕期血清25-OH-VitD水平與子宮動脈PI聯閤檢測對早髮型重度子癇前期（EOSP）的預測價值。方法選擇2013年1月～2015年1月在我院門診早孕期建卡的初次單胎妊娠無閤併癥的婦女5000例作為研究對象，孕週為8～13週+6天，用化學髮光法進行血清維生素D(25-OH-VitD)水平檢測，併記錄入選者在孕11～13週+6天測NT時行雙側子宮動脈PI值的測定。共有1748例孕婦完成研究，規律產檢併在我院分娩。實驗分組：A組維生素D水平正常+PI＜2.4；B組維生素D水平缺乏+PI＜2.4；C組維生素D水平正常+PI＞2.4；D組；維生素D水平缺乏+PI＞2.4；比較4組EOSP髮病率。結果 EOSP患者早孕期血清維生素D缺乏者為96%，低于正常孕婦，而PI值高于正常組，P＜0.05。EOSP髮病率D組最高， A組最低，均與其它三組差異明顯，P＜0.05。B與C組無明顯差異。結論早孕期維生素D缺乏可能是EOSP髮病的獨立危險因素。早孕期血清維生素D與子宮動脈PI聯閤檢測對EOSP髮病有較好的預測價值。
목적：연구조잉기혈청25-OH-VitD수평여자궁동맥PI연합검측대조발형중도자간전기（EOSP）적예측개치。방법선택2013년1월～2015년1월재아원문진조잉기건잡적초차단태임신무합병증적부녀5000례작위연구대상，잉주위8～13주+6천，용화학발광법진행혈청유생소D(25-OH-VitD)수평검측，병기록입선자재잉11～13주+6천측NT시행쌍측자궁동맥PI치적측정。공유1748례잉부완성연구，규률산검병재아원분면。실험분조：A조유생소D수평정상+PI＜2.4；B조유생소D수평결핍+PI＜2.4；C조유생소D수평정상+PI＞2.4；D조；유생소D수평결핍+PI＞2.4；비교4조EOSP발병솔。결과 EOSP환자조잉기혈청유생소D결핍자위96%，저우정상잉부，이PI치고우정상조，P＜0.05。EOSP발병솔D조최고， A조최저，균여기타삼조차이명현，P＜0.05。B여C조무명현차이。결론조잉기유생소D결핍가능시EOSP발병적독립위험인소。조잉기혈청유생소D여자궁동맥PI연합검측대EOSP발병유교호적예측개치。
Objective To study value of prediction study on early-onset severe preeclampsia (EOSP)by maternal serum 25-OH-VitD jointed with uterine artery Doppler pulsatility index (UtAD-PI) in First-trimester pregnancy.Methods 5 000 early singleton pregnancy women with gestational age 8~13weeks+6days and without any complications in our hospital outpatient department from January 2013 to January 2015 were involved. The levels of serum 25-OH-VitD were measured by chemiluminescence method. And all pregnant women’s UtAD-PI were measured when nuchal translucency (NT) measured. Only 1 748 women went through the whole study. They were divided into 4 groups, Group A included patients with serum normal Vitamin D and PI<2.4,Group B with serum Vitamin D deifciency and PI<2.4, Group C with serum normal Vitamin D and PI>2.4, Group D with serum Vitamin D deficiency and PI>2.4. The occurrence rate was calculated in different groups.Results EOSP Patients with Vitamin D deifciency were 96%, The levels of serum 25-OH-VitD was signiifcantly lower than in normal control group, And the value of PI was signiifcantly higher in EOSP than normal group,P<0.05. The occurrence rate of EOSP in group D was highest and in group A is lowest, the difference had statistically signiifcance,P<0.05. But group B and C had no signiifcantly difference in occurrence rate of EOSP.Conclusion Vitamin D deifciency in First-trimester is probably a Independent risk factor for EOSP patients. Serum 25-OH-VitDmeasuredjointed with UtAD-PI in First-trimester pregnancy could have better prediction value for EOSP.
