CAJ | 학술논문

目的：探究盐酸多奈派齐片(安理申)对脑卒中后抑郁(post stroke depression,PSD)患者认知功能及生活能力恢复的有效性。方法选择我院2011年10月—2013年9月接诊的PSD患者86例,随机分成观察组(43例)和对照组(43例)。对照组接受原发病治疗和功能康复训练,观察组在对照组的基础上给予安理申治疗。分别在治疗前和治疗后8周、16周采用蒙特利尔认知估量表(montreal cognitive Assessment,MoCA)、Fugl Meyer运动量表(FMA)及Barthel指数(BI)对患者认知、运动功能和生活活动能力进行评价。结果治疗前两组三项指标差异无统计学意义(P>0.05),而治疗后8周,观察组MoCA、FMA及BI评分为(24.5±1.9)分、(31.2±8.3)分和(35.2±7.5)分,对照组为(20.1±1.4)分、(26.3±8.1)分、(31.8±6.3)分,观察组 MoCA、FMA及 BI评分明显高于对照组(P<0.05)；治疗16周后,观察组 MoCA、FMA及 BI评分为(28.2±1.3)分、(34.1±8.8)分和(36.2±8.5)分,对照组为(22.5±1.2)分、(27.1±8.3)分、(31.6±6.8)分,观察组 MoCA、FMA和 BI得分均显著高于对照组(P<0.05)。结论安理申治疗 PSD患者能有效提升认知功能,并增强自理能力,是治疗 PSD的较佳选择之一。
목적：탐구염산다내파제편(안리신)대뇌졸중후억욱(post stroke depression,PSD)환자인지공능급생활능력회복적유효성。방법선택아원2011년10월—2013년9월접진적PSD환자86례,수궤분성관찰조(43례)화대조조(43례)。대조조접수원발병치료화공능강복훈련,관찰조재대조조적기출상급여안리신치료。분별재치료전화치료후8주、16주채용몽특리이인지고량표(montreal cognitive Assessment,MoCA)、Fugl Meyer운동량표(FMA)급Barthel지수(BI)대환자인지、운동공능화생활활동능력진행평개。결과치료전량조삼항지표차이무통계학의의(P>0.05),이치료후8주,관찰조MoCA、FMA급BI평분위(24.5±1.9)분、(31.2±8.3)분화(35.2±7.5)분,대조조위(20.1±1.4)분、(26.3±8.1)분、(31.8±6.3)분,관찰조 MoCA、FMA급 BI평분명현고우대조조(P<0.05)；치료16주후,관찰조 MoCA、FMA급 BI평분위(28.2±1.3)분、(34.1±8.8)분화(36.2±8.5)분,대조조위(22.5±1.2)분、(27.1±8.3)분、(31.6±6.8)분,관찰조 MoCA、FMA화 BI득분균현저고우대조조(P<0.05)。결론안리신치료 PSD환자능유효제승인지공능,병증강자리능력,시치료 PSD적교가선택지일。
Objective To explore the efficacy of donepezil hydrochloride on the recovery of cognitive function and ability of daily living in patients with post stroke depression(PSD).Methods Eighty six patients with PSD from October 2011 to September 2013 were selected,and were randomly divided into two groups:The control group(n=43)treated with routine treatment plus functional reha-bilitation training,the treatment group(n=43)treated with donepezil hydrochloride and routine treatment plus functional rehabilitation training.Montreal Cognitive Assessment(MoCA),Fugl Meyer Motor Scale (FMA)and Barthel Index (BI)were used to evaluate the cognitive function,motor function and ability of daily living before training,at 8 weeks and 16 weeks after treatment.Results After 8 weeks of treatment,the scores of MoCA,FMA and BI in treatment group were higher than that in control group[(24.5± 1.9)vs(20.1± 1.4),(31.2± 8.3)vs (26.3± 8.1),(35.2± 7.5)vs (31.8± 6.3),P<0.05].After 16 weeks of treatment,the scores of MoCA,FMA and BI in treatment group were higher than that in control group[(28.2± 1.3)vs (22.5± 1.2),(34.1± 8.8)vs (27.1± 8.3),(36.2± 8.5)vs (31.6± 6.8),P<0.05].Conclusion Donepezil hydrochloride can improve cognitive function and enhance the ability of self care in patients with PSD.