中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
27期
40-42
,共3页
甲状腺癌%促甲状腺激素受体%表达率%临床作用%回顾性分析
甲狀腺癌%促甲狀腺激素受體%錶達率%臨床作用%迴顧性分析
갑상선암%촉갑상선격소수체%표체솔%림상작용%회고성분석
Thyroid cancer%Thyroid stimulating hormone receptor%Expression rate%Clinical effect%Retrospective analysis
目的 分析和探讨甲状腺癌患者体内促甲状腺激素受体表达情况. 方法 对整群选取的2011年4月-2015年3月该院肿瘤科收治的65例甲状腺癌患者临床资料进行回顾性分析,选取30例甲状腺功能正常的健康人作为对照组,对采集的甲状腺组织进行HE染色观察并进行免疫组织化学检测促甲状腺激素受体在其中的表达情况. 结果 检测结果表明促甲状腺激素受体在正常甲状腺组织和甲状腺癌患者甲状腺组织中均有表达,但后者着色明显要浅,表达部位均位于细胞膜的基地侧. 在正常甲状腺组织中的阳性表达率为100.00%(30/30),显著高于甲状腺肿瘤患者的84.84%(28/33)和甲状腺癌患者的68.75%(22/32). 并且甲状腺肿瘤患者的阳性率显著高于甲状腺癌患者,差异有统计学意义(P<0.05). 结论 该研究结果表明,在正常的甲状腺组织中促甲状腺激素受体具有较高表达,随着甲状腺组织分化程度的降低其表达率明显下降,这一结论为临床上分化型甲状腺癌患者的TSH抑制疗法提供了重要的数据参考.
目的 分析和探討甲狀腺癌患者體內促甲狀腺激素受體錶達情況. 方法 對整群選取的2011年4月-2015年3月該院腫瘤科收治的65例甲狀腺癌患者臨床資料進行迴顧性分析,選取30例甲狀腺功能正常的健康人作為對照組,對採集的甲狀腺組織進行HE染色觀察併進行免疫組織化學檢測促甲狀腺激素受體在其中的錶達情況. 結果 檢測結果錶明促甲狀腺激素受體在正常甲狀腺組織和甲狀腺癌患者甲狀腺組織中均有錶達,但後者著色明顯要淺,錶達部位均位于細胞膜的基地側. 在正常甲狀腺組織中的暘性錶達率為100.00%(30/30),顯著高于甲狀腺腫瘤患者的84.84%(28/33)和甲狀腺癌患者的68.75%(22/32). 併且甲狀腺腫瘤患者的暘性率顯著高于甲狀腺癌患者,差異有統計學意義(P<0.05). 結論 該研究結果錶明,在正常的甲狀腺組織中促甲狀腺激素受體具有較高錶達,隨著甲狀腺組織分化程度的降低其錶達率明顯下降,這一結論為臨床上分化型甲狀腺癌患者的TSH抑製療法提供瞭重要的數據參攷.
목적 분석화탐토갑상선암환자체내촉갑상선격소수체표체정황. 방법 대정군선취적2011년4월-2015년3월해원종류과수치적65례갑상선암환자림상자료진행회고성분석,선취30례갑상선공능정상적건강인작위대조조,대채집적갑상선조직진행HE염색관찰병진행면역조직화학검측촉갑상선격소수체재기중적표체정황. 결과 검측결과표명촉갑상선격소수체재정상갑상선조직화갑상선암환자갑상선조직중균유표체,단후자착색명현요천,표체부위균위우세포막적기지측. 재정상갑상선조직중적양성표체솔위100.00%(30/30),현저고우갑상선종류환자적84.84%(28/33)화갑상선암환자적68.75%(22/32). 병차갑상선종류환자적양성솔현저고우갑상선암환자,차이유통계학의의(P<0.05). 결론 해연구결과표명,재정상적갑상선조직중촉갑상선격소수체구유교고표체,수착갑상선조직분화정도적강저기표체솔명현하강,저일결론위림상상분화형갑상선암환자적TSH억제요법제공료중요적수거삼고.
Objective To analyze and investigate the expression of thyroid stimulating hormone receptor in thyroid cancer patients. Methods A retrospective analysis was conducted on the clinical data of thyroid cancer patients admitted in the Oncology Depart-ment of our hospital from April 2011 to March 2015. And other 30 healthy people with normal thyroid function were selected as the control group. The thyroid tissues of the thyroid cancer patients and control group were stained by HE staining and measured by immunohistochemistry for detecting the expression of thyroid stimulating hormone receptor. Results The results showed that thy-roid stimulating hormone receptor in normal thyroid tissue and the thyroid tissue of thyroid cancer patients expressed, but the latter coloring was shallow, the expression site was located in the base side of the cell membrane. The positive expression rate of thyroid stimulating hormone receptor in the normal thyroid tissues was 100% (30/30), significantly higher than 84.84% (28/33) in thyroid tumor patients and 68.75%(22/32) in thyroid cancer patients. And the positive rate of thyroid stimulating hormone receptor in thy-roid tumor patients was significantly higher than that in thyroid cancer patients with statistically significant difference ( P<0.05). Conclusion The results suggested that the expression of thyroid stimulating hormone receptor in the normal thyroid tissue is high-er, but with the degree of differentiation of the thyroid tissue decreases, the expression decreases significantly, which provides an important reference for the TSH suppression therapy in differentiated thyroid cancer patients.
