CAJ | 학술논문

目的：研究急性心肌梗死(AMI)患者经皮冠状动脉成形术后高敏 C反应蛋白(hsCRP)、心肌肌钙蛋白 I(cTnI)、脑钠肽(BNP)浓度与预后的关系。方法筛选2013年6月—2014年6月我科收治的急性心肌梗死并行经皮冠状动脉成形术和常规治疗的患者50例作为观察组(OG),同时筛选急性心肌梗死行内科药物治疗的患者50例作为对照组(CG)和非心肌梗死患者50例作为空白组(BG)。经皮冠状动脉成形术后1 d、7 d,分别检测3组患者静脉血中 BNP、cTnI、hsCRP浓度。随访3组患者半年内的主要不良心脏事件,对比分析3组患者血浆指标及主要不良心脏事件。结果术后1 d,CG组和OG组患者静脉血中BNP、cTnI、hsCRP浓度均显著高于与 BG组患者(P<0.01),但 CG组患者和 OG组患者的此3个血浆指标比较差异无统计学意义(P>0.05)。术后7 d,CG组和 OG组患者静脉血中 BNP、cTnI、hsCRP浓度均仍显著高于与 BG组患者(P<0.01)。CG组患者 hsCRP浓度显著高于 OG组患者[(12.9±4.1)mg/L vs(7.5±0.5)mg/L,P<0.01]。CG组患者 BNP浓度显著高于 OG组患者[(1993±202)ng/L vs(331±30)ng/L,P<0.01]。CG组患者cTnI平均浓度显著高于OG组患者[(7.4±0.4)ng/L vs (2.6±0.2)ng/L,P<0.01]。CG组患者主要不良心脏事件发生率高于 OG组患者(48.0% vs 18.0%,P<0.01)。结论对于急性心肌梗死患者,经皮冠状动脉成形术后内心肌肌钙蛋白 I、高敏 C反应蛋白、脑钠肽能够反映急性心肌梗死患者的预后程度。
목적：연구급성심기경사(AMI)환자경피관상동맥성형술후고민 C반응단백(hsCRP)、심기기개단백 I(cTnI)、뇌납태(BNP)농도여예후적관계。방법사선2013년6월—2014년6월아과수치적급성심기경사병행경피관상동맥성형술화상규치료적환자50례작위관찰조(OG),동시사선급성심기경사행내과약물치료적환자50례작위대조조(CG)화비심기경사환자50례작위공백조(BG)。경피관상동맥성형술후1 d、7 d,분별검측3조환자정맥혈중 BNP、cTnI、hsCRP농도。수방3조환자반년내적주요불양심장사건,대비분석3조환자혈장지표급주요불양심장사건。결과술후1 d,CG조화OG조환자정맥혈중BNP、cTnI、hsCRP농도균현저고우여 BG조환자(P<0.01),단 CG조환자화 OG조환자적차3개혈장지표비교차이무통계학의의(P>0.05)。술후7 d,CG조화 OG조환자정맥혈중 BNP、cTnI、hsCRP농도균잉현저고우여 BG조환자(P<0.01)。CG조환자 hsCRP농도현저고우 OG조환자[(12.9±4.1)mg/L vs(7.5±0.5)mg/L,P<0.01]。CG조환자 BNP농도현저고우 OG조환자[(1993±202)ng/L vs(331±30)ng/L,P<0.01]。CG조환자cTnI평균농도현저고우OG조환자[(7.4±0.4)ng/L vs (2.6±0.2)ng/L,P<0.01]。CG조환자주요불양심장사건발생솔고우 OG조환자(48.0% vs 18.0%,P<0.01)。결론대우급성심기경사환자,경피관상동맥성형술후내심기기개단백 I、고민 C반응단백、뇌납태능구반영급성심기경사환자적예후정도。
Objective To investigate the relationship between the concentrations of brain natriuretic peptide (BNP),high sensitivity C reactive protein (hsCRP),cardiac troponin I (cTnI)and prognosis in patients with acute myocardial infarction(AMI)after percutane-ous transluminal coronary angioplasty(PTCA).Methods Fifty patients with AMI after PTCA and conventional treatment which were conducted in our department from June 2013 to June 2014 were screened out and named as the observation group(OG).Fifty pa-tients with AMI undergone simple conventional treatment were screened out and named as the control group (CG).Fifty patients with un AMI treated by simple conventional treatment were screened out and named as the blank group (BG).The concentrations of BNP,cTnI,hsCRP in three groups were measured in the 1st and 7th day after PTCA.The major adverse cardiac events (MACE)were observed within six months.Results The concentrations of plasma BNP,cTnI,hsCRP in CG and OG were significantly higher than that in BG after 1 day of PTCA(P<0.01).There was no significant difference in BNP,cTnI,hsCRP between CG and OG(P>0.05). The concentrations of plasma BNP,cTnI,hsCRP in CG and OG were significantly higher than that in BG after 7 days of PTCA(P<0.01).The concentrations of plasma hsCRP,BNP,cTnI in CG were significantly higher than that in OG [(12.9±4.1)mg/L vs (7.5±0.5) mg/L,(1 993± 202)ng/L vs (331± 30)ng/L,(7.4± 0.4)ng/L vs (2.6± 0.2)ng/L,P<0.01].The incidence of MACE in CG was higher than that in OG(48.0% vs 18.0%,P<0.01).Conclusion The concentrations of plasma BNP,cTnI,and hsCRP can predict the prog-nosis in patients with AMI fol oning PTCA.