CAJ | 학술논문

目的：探讨定心颗粒治疗高血压病合并频发性室早的临床疗效。方法将100例患者随机分为2组，即观察组和对照组，每组各50例。两组均给予相同降压药及琥珀酸美托洛尔缓释片治疗，观察组在此基础上给予中药协定方定心颗粒；两组均予试验观察治疗4周，观察两组试验前后hs-CRP水平、24 h动态心电图的变化，并比较室性早搏的治疗效果。结果观察组可显著降低患者hs-CRP水平及减少室早的次数，与对照组比较有统计学意义（P＜0.01），且对室早的疗效优于对照组（P＜0.01）。同时，观察组治疗后平均心率降低不明显，无统计学意义（P＞0.05）。结论定心颗粒对稳定心室率具有一定的作用，联合美托洛尔治疗高血压病合并频发性室早患者可显著降低hs-CRP水平及减少室早次数，且对室早疗效显著。
목적：탐토정심과립치료고혈압병합병빈발성실조적림상료효。방법장100례환자수궤분위2조，즉관찰조화대조조，매조각50례。량조균급여상동강압약급호박산미탁락이완석편치료，관찰조재차기출상급여중약협정방정심과립；량조균여시험관찰치료4주，관찰량조시험전후hs-CRP수평、24 h동태심전도적변화，병비교실성조박적치료효과。결과관찰조가현저강저환자hs-CRP수평급감소실조적차수，여대조조비교유통계학의의（P＜0.01），차대실조적료효우우대조조（P＜0.01）。동시，관찰조치료후평균심솔강저불명현，무통계학의의（P＞0.05）。결론정심과립대은정심실솔구유일정적작용，연합미탁락이치료고혈압병합병빈발성실조환자가현저강저hs-CRP수평급감소실조차수，차대실조료효현저。
Objective To investigate the Dingxin granule treatment of hypertension complicated with frequent clinical curative effect of early ventricular.Methods 100 patients were randomly divided into 2 groups, the observation group and the control group, 50 cases in each group. Two groups were given the same antihypertensive drugs and metoprolol succinate sustained-release tablets in the treatment, the observation given traditional Chinese medicine prescription of Dingxin granule group on the basis of; two groups were given experimental observation on treatment for 4 weeks, to observe the changes of the two groups before and after the test hs CRP level, 24 dynamic electrocardiogram, and ventricular premature beat the therapeutic effect.ResultsThe observation group can signiifcantly reduce the hs-CRP level and reduce the number of early times, compared with the control group (P<0.01), and the effect of early treatment is better than the control group (P<0.01). At the same time, the average heart rate of the observation group was not signiifcantly decreased, no signiifcant (P>0.05). Conclusion Dingxin Granule on the stability of ventricular rate has a certain role, combined with metoprolol in the treatment of hypertensive disease with frequent ventricular early patients can signiifcantly reduce hs CRP levels and reduced the number of PVCs and for room early curative effect to be remarkable.