CAJ | 학술논문

目的：通过查阅文献并对文献进行分析，汇总注射用血栓通（冻干）所致不良反应的影响因素及临床表现，为临床合理使用该药提供理论支持。方法检索2000年1月—2014年12月报道的注射用血栓通（冻干）不良反应/事件文献数据，制定严格的文献纳入和排除标准，提取文献中报道的病例信息并对信息进行分类统计及分析。结果使用注射用血栓通（冻干）导致不良反应就性别比例上女性略高于男性；老年患者及有过敏史的患者在使用注射用血栓通（冻干）后更易发生不良反应；不良反应临床表现复杂多样，主要体现为：皮肤及附件损害、全身性损害及消化系统损害等多个方面，其中以皮肤及附件损害所占比例最大。结论注射用血栓通（冻干）导致不良反应临床表现涉及多个脏器及系统，不良反应影响因素多样，医、药、护等工作人员在临床使用中进行严密监测以保证患者用药安全性；通过文献研究法可以发现该药上市后新的不良反应及影响因素，可以做为发现该药上市后安全性研究的补充资料。
목적：통과사열문헌병대문헌진행분석，회총주사용혈전통（동간）소치불량반응적영향인소급림상표현，위림상합리사용해약제공이론지지。방법검색2000년1월—2014년12월보도적주사용혈전통（동간）불량반응/사건문헌수거，제정엄격적문헌납입화배제표준，제취문헌중보도적병례신식병대신식진행분류통계급분석。결과사용주사용혈전통（동간）도치불량반응취성별비례상녀성략고우남성；노년환자급유과민사적환자재사용주사용혈전통（동간）후경역발생불량반응；불량반응림상표현복잡다양，주요체현위：피부급부건손해、전신성손해급소화계통손해등다개방면，기중이피부급부건손해소점비례최대。결론주사용혈전통（동간）도치불량반응림상표현섭급다개장기급계통，불량반응영향인소다양，의、약、호등공작인원재림상사용중진행엄밀감측이보증환자용약안전성；통과문헌연구법가이발현해약상시후신적불량반응급영향인소，가이주위발현해약상시후안전성연구적보충자료。
Objective Summarize the influence factors and clinical manifestations of adverse reactions caused by injection of thrombus (freeze-dried), through literature review and analysis to provide theoretical support for clinical rational use of the drug. Methods To develop a strict literature on the inclusion and exclusion criteria ,which was used to extract the infor-mation of the cases reported in the literature and analyze the information which was reported from January 2000 to Decem-ber 2014. Results The sex ratio of women was slightly higher than that of males by using the injection of thrombus (freeze dry) . Older patients and patients with allergic history were more likely to have adverse reactions after using the injection of thrombus (freeze-dried). The clinical manifestations of adverse reactions are complex and diverse, mainly reflected in the skin and accessories damage, systemic damage and digestive system damage, etc., in which the proportion of skin and ac-cessories damage is the largest. Conclusion The clinical manifestations of adverse reactions caused by injection of thrombus (freeze-dried) are related to multiple organs and systems, and adverse effects are diverse, doctor, Pharmacist, nurse and oth-er staff in clinical use to ensure the safety of patients. Through literature research, we can find that the new adverse reaction and the influencing factors of the drug market, which can be used as a supplementary material for the study of the safety of the drug.