CAJ | 학술논문

目的探讨血清脑钠肽 ( BNP) 和肌红蛋白 ( MYO) 在慢性心力衰竭患者中的检测及临床意义. 方法选择2013年8月至2015年1月我院心内科收治122例慢性心力衰竭患者, 设为观察组, 另将同期于我院体检的健康志愿者34例作为对照组, 检测所有受试者血清BNP和MYO水平, 其中BNP采用化学发光法检测, MYO采用酶联免疫吸附法检测.结果观察组患者血清BNP和MYO分别为 (698. 4±207. 9) pg/mL和 (133. 6±42. 1) ng/mL, 均显著高于对照组, 差异有统计学意义 (P<0. 05); 随着心功能分级的增加, 血清BNP和MYO呈显著增高, 差异有统计学意义 (P<0. 05), 心功能为Ⅳ级患者血清BNP和MYO显著高于心功能为Ⅱ级和Ⅲ级患者, 而心功能为Ⅲ级患者血清BNP和MYO显著高于心功能为Ⅱ级患者, 差异均有统计学意义 (均P<0. 05). 结论慢性心力衰竭患者血清中BNP和MYO显著升高, 且与心功能严重程度密切相关, 其可能成为慢性心力衰竭早期诊断、病情评估和预后判定的重要指标, 具有重要的临床意义.
목적 탐토혈청뇌납태 ( BNP) 화기홍단백 ( MYO) 재만성심력쇠갈환자중적검측급림상의의. 방법 선택2013년8월지2015년1월아원심내과수치122례만성심력쇠갈환자, 설위관찰조, 령장동기우아원체검적건강지원자34례작위대조조, 검측소유수시자혈청BNP화MYO수평, 기중BNP채용화학발광법검측, MYO채용매련면역흡부법검측.결과 관찰조환자혈청BNP화MYO분별위 (698. 4±207. 9) pg/mL화 (133. 6±42. 1) ng/mL, 균현저고우대조조, 차이유통계학의의 (P<0. 05); 수착심공능분급적증가, 혈청BNP화MYO정현저증고, 차이유통계학의의 (P<0. 05), 심공능위Ⅳ급환자혈청BNP화MYO현저고우심공능위Ⅱ급화Ⅲ급환자, 이심공능위Ⅲ급환자혈청BNP화MYO현저고우심공능위Ⅱ급환자, 차이균유통계학의의 (균P<0. 05). 결론 만성심력쇠갈환자혈청중BNP화MYO현저승고, 차여심공능엄중정도밀절상관, 기가능성위만성심력쇠갈조기진단、 병정평고화예후판정적중요지표, 구유중요적림상의의.
Objective To explore the detection and clinical significance of serum brain natriuretic peptide ( BNP) and myoglobin ( MYO) on patients with chronic heart failure. Methods 122 patients with chronic heart failure in our hospital from August 2013 to January 2015 were chosen as observation group; 34 healthy volunteers during the same period were chosen as control group. Serum BNP and MYO of all participants were detected. BNP was detected by chemiluminescence method, and MYO was detected by enzyme-linked immunosorbent assay. Results Levels of serum BNP and MYO in the observation group were ( 698. 4 ± 207. 9 ) pg/mL and (133. 6±42. 1) ng/mL respectively, significantly higher than that of the control group. The difference was statistically significant (P<0. 05) . With the increase of cardiac function classification, serum BNP and MYO significantly increased. The difference was statisti-cally significant (P<0. 05). Levels of serum BNP and MYO on patients with Ⅳ grade cardiac function were significantly higher than that of patients with Ⅱand Ⅲ grade cardiac function, while those on patients with Ⅲ grade cardiac function were significantly higher than that of patients withⅡgrade cardiac function. The differences were statistically significant (P<0. 05). Conclusion Serum BNP and MYO in patients with chronic heart failure significantly increase and are closely related to the severity of heart function. They may become important indexes for early diagnosis, disease evaluation and prognosis on patients with chronic heart failure, which is of great clinical significance.