CAJ | 학술논문

目的米氮平联合不同剂量氨磺必利治疗抑郁症的临床疗效. 方法选取120例抑郁患者为研究对象, 随机分为研究组 (n=60) 和对照组 (n=60). 对照组给予氨磺必利 (50 mg/d) +米氮平 (15 mg/d), 研究组给予氨磺必利 (100 mg/d) +米氮平 (15 mg/d). 比较两组汉密尔顿抑郁量表17项 (HAMD-17) 评分及临床疗效. 结果治疗后, 研究组患者HAMD-17评分显著低于对照组, 组间差异具有统计学意义 (P<0. 05). 研究组治疗有效率显著高于对照组 (P<0. 05).对照组和研究组不良反应发生率分别为30. 0% ( 15/50 )、 12. 0% ( 6/50 ) , 研究组不良反应发生率显著低于对照组 ( P<0. 05). 结论 100 mg/d氨磺必利联合15 mg/d米氮平治疗抑郁症效果优于50 mg/d氨磺必利联合15 mg/d米氮平, 但其不良反应发生率也明显增加.
목적 미담평연합불동제량안광필리치료억욱증적림상료효. 방법 선취120례억욱환자위연구대상, 수궤분위연구조 (n=60) 화대조조 (n=60). 대조조급여안광필리 (50 mg/d) +미담평 (15 mg/d), 연구조급여안광필리 (100 mg/d) +미담평 (15 mg/d). 비교량조한밀이돈억욱량표17항 (HAMD-17) 평분급림상료효. 결과 치료후, 연구조환자HAMD-17평분현저저우대조조, 조간차이구유통계학의의 (P<0. 05). 연구조치료유효솔현저고우대조조 (P<0. 05).대조조화연구조불량반응발생솔분별위30. 0% ( 15/50 )、 12. 0% ( 6/50 ) , 연구조불량반응발생솔현저저우대조조 ( P<0. 05). 결론 100 mg/d안광필리연합15 mg/d미담평치료억욱증효과우우50 mg/d안광필리연합15 mg/d미담평, 단기불량반응발생솔야명현증가.
Objective To evaluate the clinical effect of mirtazapine combined with different doses of amisulpride on depression. Methods 120 patients with depression were randomly divided into observation group (n=60) and control group (n=60). The con-trol group was given amisulpride (50 mg/d) + mirt azapine (15 mg/d). The observation group was given amisulpride (100 mg/d)+ mirtazapine (15 mg/d). The HAMD-17 score and clinical effect were compared between the two groups. Results After treat-ment, the HAMD-17 score of the research group significantly decreased, compared with the control group, with statistically significant difference (P<0. 05). The clinical effect of the research group was significantly better than that of the control group, with statistical significance (P<0. 05). The untoward effect rate of research group and control group was 30. 0% (15/50) and 12. 0% (6/50) re-spectively, with statistically significant difference ( P<0. 05 ) . Conclusion The therapy of 100 mg/d amisulpride combined with 15 mg/d mirtazapine proves superior to 50 mg/d amisulpride combined with 15 mg/d mirtazapine, but along with significantly increased incidence of adverse reactions.