CAJ | 학술논문

目的：了解维吾尔族和汉族老年人血清骨保护素( OPG)水平与骨量的关系。方法于2011年10月—2013年12月，选取在新疆医科大学第一附属医院干部病房接受住院治疗的维吾尔族和汉族老年人375例。根据骨密度(BMD)测定结果，将其分为骨量异常组(n=239)和骨量正常组(n=136)。比较不同骨量情况、民族、性别、年龄老年人的血清OPG水平，并探讨血清OPG水平与骨量的相关关系。结果(1)骨量正常组与骨量异常组老年人血清OPG水平比较，差异有统计学意义(P<0．05)。按民族分层：两组老年人血清OPG水平比较，差异无统计学意义(P>0．05)。按性别分层：两组男性老年人血清OPG水平比较，差异有统计学意义(P<0．05)；而两组女性老年人血清OPG水平比较，差异无统计学意义(P>0．05)。(2)不同民族老年人血清OPG水平比较，差异有统计学意义(P<0．05)。按性别分层：不同民族男性老年人血清OPG水平比较，差异有统计学意义(P<0．05)；不同民族女性老年人血清OPG水平比较，差异无统计学意义( P>0．05)。按骨量正常与否分层：不同民族骨量正常老年人血清OPG水平比较，差异有统计学意义( P<0．05)；不同民族骨量异常老年人血清OPG水平比较，差异无统计学意义( P>0．05)。(3)不同性别老年人血清OPG水平比较，差异无统计学意义(P>0．05)。按民族和骨量正常与否分层后，不同性别老年人血清OPG水平比较，差异亦无统计学意义(P>0．05)。(4)不同年龄老年人血清OPG水平比较，差异无统计学意义(P>0．05)。按民族和骨量正常与否分层后，不同年龄老年人血清OPG水平比较，差异亦无统计学意义(P>0．05)。(5) Spearman秩相关分析显示：汉族男性老年人和维吾尔族女性老年人血清OPG水平与骨量无相关关系(P>0．05)；维吾尔族男性老年人血清OPG水平与骨量存在正相关关系(P<0．05)；而汉族女性老年人血清OPG水平与股骨颈、大转子、小转子及髋关节部位骨量存在负相关关系(P<0．05)。结论维吾尔族老年人的血清OPG水平低于汉族老年人；骨量异常老年人的血清OPG水平低于骨量正常老年人。维吾尔族男性老年人的血清OPG水平与骨量呈正相关关系，而汉族女性老年人的血清OPG水平与股骨颈、大转子、小转子及髋关节部位的骨量呈负相关关系。目的：瞭解維吾爾族和漢族老年人血清骨保護素( OPG)水平與骨量的關繫。方法于2011年10月—2013年12月，選取在新疆醫科大學第一附屬醫院榦部病房接受住院治療的維吾爾族和漢族老年人375例。根據骨密度(BMD)測定結果，將其分為骨量異常組(n=239)和骨量正常組(n=136)。比較不同骨量情況、民族、性彆、年齡老年人的血清OPG水平，併探討血清OPG水平與骨量的相關關繫。結果(1)骨量正常組與骨量異常組老年人血清OPG水平比較，差異有統計學意義(P<0．05)。按民族分層：兩組老年人血清OPG水平比較，差異無統計學意義(P>0．05)。按性彆分層：兩組男性老年人血清OPG水平比較，差異有統計學意義(P<0．05)；而兩組女性老年人血清OPG水平比較，差異無統計學意義(P>0．05)。(2)不同民族老年人血清OPG水平比較，差異有統計學意義(P<0．05)。按性彆分層：不同民族男性老年人血清OPG水平比較，差異有統計學意義(P<0．05)；不同民族女性老年人血清OPG水平比較，差異無統計學意義( P>0．05)。按骨量正常與否分層：不同民族骨量正常老年人血清OPG水平比較，差異有統計學意義( P<0．05)；不同民族骨量異常老年人血清OPG水平比較，差異無統計學意義( P>0．05)。(3)不同性彆老年人血清OPG水平比較，差異無統計學意義(P>0．05)。按民族和骨量正常與否分層後，不同性彆老年人血清OPG水平比較，差異亦無統計學意義(P>0．05)。(4)不同年齡老年人血清OPG水平比較，差異無統計學意義(P>0．05)。按民族和骨量正常與否分層後，不同年齡老年人血清OPG水平比較，差異亦無統計學意義(P>0．05)。(5) Spearman秩相關分析顯示：漢族男性老年人和維吾爾族女性老年人血清OPG水平與骨量無相關關繫(P>0．05)；維吾爾族男性老年人血清OPG水平與骨量存在正相關關繫(P<0．05)；而漢族女性老年人血清OPG水平與股骨頸、大轉子、小轉子及髖關節部位骨量存在負相關關繫(P<0．05)。結論維吾爾族老年人的血清OPG水平低于漢族老年人；骨量異常老年人的血清OPG水平低于骨量正常老年人。維吾爾族男性老年人的血清OPG水平與骨量呈正相關關繫，而漢族女性老年人的血清OPG水平與股骨頸、大轉子、小轉子及髖關節部位的骨量呈負相關關繫。
목적：료해유오이족화한족노년인혈청골보호소( OPG)수평여골량적관계。방법우2011년10월—2013년12월，선취재신강의과대학제일부속의원간부병방접수주원치료적유오이족화한족노년인375례。근거골밀도(BMD)측정결과，장기분위골량이상조(n=239)화골량정상조(n=136)。비교불동골량정황、민족、성별、년령노년인적혈청OPG수평，병탐토혈청OPG수평여골량적상관관계。결과(1)골량정상조여골량이상조노년인혈청OPG수평비교，차이유통계학의의(P<0．05)。안민족분층：량조노년인혈청OPG수평비교，차이무통계학의의(P>0．05)。안성별분층：량조남성노년인혈청OPG수평비교，차이유통계학의의(P<0．05)；이량조녀성노년인혈청OPG수평비교，차이무통계학의의(P>0．05)。(2)불동민족노년인혈청OPG수평비교，차이유통계학의의(P<0．05)。안성별분층：불동민족남성노년인혈청OPG수평비교，차이유통계학의의(P<0．05)；불동민족녀성노년인혈청OPG수평비교，차이무통계학의의( P>0．05)。안골량정상여부분층：불동민족골량정상노년인혈청OPG수평비교，차이유통계학의의( P<0．05)；불동민족골량이상노년인혈청OPG수평비교，차이무통계학의의( P>0．05)。(3)불동성별노년인혈청OPG수평비교，차이무통계학의의(P>0．05)。안민족화골량정상여부분층후，불동성별노년인혈청OPG수평비교，차이역무통계학의의(P>0．05)。(4)불동년령노년인혈청OPG수평비교，차이무통계학의의(P>0．05)。안민족화골량정상여부분층후，불동년령노년인혈청OPG수평비교，차이역무통계학의의(P>0．05)。(5) Spearman질상관분석현시：한족남성노년인화유오이족녀성노년인혈청OPG수평여골량무상관관계(P>0．05)；유오이족남성노년인혈청OPG수평여골량존재정상관관계(P<0．05)；이한족녀성노년인혈청OPG수평여고골경、대전자、소전자급관관절부위골량존재부상관관계(P<0．05)。결론유오이족노년인적혈청OPG수평저우한족노년인；골량이상노년인적혈청OPG수평저우골량정상노년인。유오이족남성노년인적혈청OPG수평여골량정정상관관계，이한족녀성노년인적혈청OPG수평여고골경、대전자、소전자급관관절부위적골량정부상관관계。
Objective To explore the correlation between serum osteoprotegerin ( OPG ) and bone mineral density among Uygur and Han elderly populations. Methods We enrolled 375 Uygur and Han elderly people who were admitted into the cadre′s ward of the First Affiliated Hospital of Xinjiang Medical University from October 2011 to December 2013. According to the examination results of BMD, the subjects were divided into two groups: abnormal BMD group (n=239) and normal BMD group ( n=136 ) . Comparison was made in serum OPG level among subjects with different BMD conditions, ethnic groups, genders and ages, and the correlation between serum OPG level and BMD was investigated. Results ( 1 ) The two groups were significantly different (P<0. 05) in serum OPG level. The two groups were not significantly different (P>0. 05) in the serum OPG level of Uygur subjects or Han subjects. The two groups were significantly different ( P<0. 05 ) in the serum OPG level of male subjects, while no significant difference (P>0. 05) was noted in the serum OPG level of female subjects between the two groups. (2) There was significant difference (P<0. 05) in serum OPG level between Uygur subjects and Han subjects. Uygur subjects and Han subjects were significantly different (P<0. 05) in the serum OPG level of male subjects, while no significant difference ( P>0. 05 ) was found in the serum OPG level of female subjects between Uygur subjects and Han subjects. Uygur subjects and Han subjects were significantly different ( P <0. 05 ) in the serum OPG level of normal BMD group, while no significant difference ( P>0. 05 ) was noted in the serum OPG level of abnormal BMD group between Uygur subjects and Han subjects. (3) Subjects of two genders were not significantly different (P>0. 05) in serum OPG level. Between Uygur subjects and Han subjects and between normal BMD group and abnormal BMD group, there was no significant difference (P>0. 05) in the serum OPG level of each gender. (4) Subjects with different ages were not significantly different (P>0. 05) in serum OPG level. Between Uygur subjects and Han subjects and between normal BMD group and abnormal BMD group, no significant difference (P>0. 05) was noted in the serum OPG level of subjects of each age range. (5) Spearman rank correlation showed that no correlation (P>0. 05) was found between serum OPG level and BMD in Han male subjects and Uygur female subjects;there was positive correlation (P<0. 05) between serum OPG level and BMD in Uygur male subjects; negative correlation (P<0. 05) was noted between serum OPG level and BMD in neck of femur, greater trochanter, lesser trochanter and hip joint among Han female subjects. Conclusion Uygur elder people are lower than Han elder people in serum OPG level, and the elderly with abnormal BMD are lower than the elderly with normal BMD in serum OPG. There is positive correlation between serum OPG level and BMD in Uygur male elderly people, and there is negative correlation between serum OPG level and BMD in neck of femur, greater trochanter, lesser trochanter and hip joint among Han female elderly people.