实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
9期
45-47
,共3页
黏膜皮肤淋巴结综合征%儿童%丙种球蛋白%疗效比较研究
黏膜皮膚淋巴結綜閤徵%兒童%丙種毬蛋白%療效比較研究
점막피부림파결종합정%인동%병충구단백%료효비교연구
Mucocutaneous lymph node syndrome%Child%Gamma - globulins%Comparative effectiveness research
目的：比较不同剂量丙种球蛋白治疗小儿川崎病的临床疗效。方法选取南宁市妇幼保健院2011年5月—2013年3月收治的98例川崎病患儿，随机分为低剂量组和高剂量组，每组49例。低剂量组患儿给予阿司匹林联合低剂量丙种球蛋白（0.5 g/ kg，2次/ d）治疗，高剂量组患儿给予阿司匹林联合高剂量丙种球蛋白（2.0 g/ kg，2次/d）治疗；两组患儿均治疗10 d。比较两组患儿临床症状（黏膜充血、手足肿胀、发热、淋巴肿大）消退时间、住院时间及临床疗效，治疗前后实验室检查指标〔白细胞计数（WBC）、血小板计数（PLT）、C 反应蛋白（CRP）、降钙素原（PCT）〕。结果两组患儿手足肿胀消退时间比较，差异无统计学意义（P >0.05）；低剂量组患儿黏膜充血消退时间、发热消退时间、淋巴肿大消退时间及住院时间均长于高剂量组（P <0.05）。治疗前两组患儿 WBC、PLT 及 CRP、PCT 水平比较，差异无统计学意义（P >0.05）；治疗后高剂量组患儿 WBC、PLT 及 CRP、PCT 水平均低于低剂量组（P <0.05）。高剂量组患儿临床疗效优于低剂量组（u =1.763，P <0.05）。结论高剂量丙种球蛋白（2.0 g/ kg，2次/ d）治疗小儿川崎病的临床疗效优于低剂量丙种球蛋白，且能快速改善患儿的临床症状及实验室检查指标。
目的：比較不同劑量丙種毬蛋白治療小兒川崎病的臨床療效。方法選取南寧市婦幼保健院2011年5月—2013年3月收治的98例川崎病患兒，隨機分為低劑量組和高劑量組，每組49例。低劑量組患兒給予阿司匹林聯閤低劑量丙種毬蛋白（0.5 g/ kg，2次/ d）治療，高劑量組患兒給予阿司匹林聯閤高劑量丙種毬蛋白（2.0 g/ kg，2次/d）治療；兩組患兒均治療10 d。比較兩組患兒臨床癥狀（黏膜充血、手足腫脹、髮熱、淋巴腫大）消退時間、住院時間及臨床療效，治療前後實驗室檢查指標〔白細胞計數（WBC）、血小闆計數（PLT）、C 反應蛋白（CRP）、降鈣素原（PCT）〕。結果兩組患兒手足腫脹消退時間比較，差異無統計學意義（P >0.05）；低劑量組患兒黏膜充血消退時間、髮熱消退時間、淋巴腫大消退時間及住院時間均長于高劑量組（P <0.05）。治療前兩組患兒 WBC、PLT 及 CRP、PCT 水平比較，差異無統計學意義（P >0.05）；治療後高劑量組患兒 WBC、PLT 及 CRP、PCT 水平均低于低劑量組（P <0.05）。高劑量組患兒臨床療效優于低劑量組（u =1.763，P <0.05）。結論高劑量丙種毬蛋白（2.0 g/ kg，2次/ d）治療小兒川崎病的臨床療效優于低劑量丙種毬蛋白，且能快速改善患兒的臨床癥狀及實驗室檢查指標。
목적：비교불동제량병충구단백치료소인천기병적림상료효。방법선취남저시부유보건원2011년5월—2013년3월수치적98례천기병환인，수궤분위저제량조화고제량조，매조49례。저제량조환인급여아사필림연합저제량병충구단백（0.5 g/ kg，2차/ d）치료，고제량조환인급여아사필림연합고제량병충구단백（2.0 g/ kg，2차/d）치료；량조환인균치료10 d。비교량조환인림상증상（점막충혈、수족종창、발열、림파종대）소퇴시간、주원시간급림상료효，치료전후실험실검사지표〔백세포계수（WBC）、혈소판계수（PLT）、C 반응단백（CRP）、강개소원（PCT）〕。결과량조환인수족종창소퇴시간비교，차이무통계학의의（P >0.05）；저제량조환인점막충혈소퇴시간、발열소퇴시간、림파종대소퇴시간급주원시간균장우고제량조（P <0.05）。치료전량조환인 WBC、PLT 급 CRP、PCT 수평비교，차이무통계학의의（P >0.05）；치료후고제량조환인 WBC、PLT 급 CRP、PCT 수평균저우저제량조（P <0.05）。고제량조환인림상료효우우저제량조（u =1.763，P <0.05）。결론고제량병충구단백（2.0 g/ kg，2차/ d）치료소인천기병적림상료효우우저제량병충구단백，차능쾌속개선환인적림상증상급실험실검사지표。
Objective To compare the clinical effect on Kawasaki disease in children between small - dose and large- dose gamma globulin. Methods A total of 98 children with Kawasaki disease were selected in Maternity and Child Care Center of Nanning from May 2011 to March 2013,and they were randomly divided into A group and B group,each of 49 cases. Children of A group were given aspirin combined with small - dose gamma globulin(0. 5 g/ kg,twice per day),while children of B group were given aspirin combined with large - dose gamma globulin(2. 0 g/ kg,twice per day),both groups treated for 10 days. Clinical symptoms ( including mucosal hyperemia, hands and feet swelling, fever and lymph node enlargement)disappeared time,hospital stays,clinical effect,laboratory examination results( including WBC,PLT,CRP and PCT)before and after treatment were compared between the two groups. Results No statistically significant differences of hands and feet swelling disappeared time was found between the two groups(P > 0. 05);while mucosal hyperemia,fever and lymph node enlargement disappeared time,hospital stays of A group were statistically significantly longer than those of B group (P < 0. 05). No statistically significant differences of WBC,PLT,CRP or PCT was found between the two groups before treatment(P > 0. 05);while WBC,PLT,CRP and PCT of B group were statistically significantly lower than those of A group after treatment(P < 0. 05). The clinical effect of B group was statistically significantly better than that of A group(u = 1. 763, P < 0. 05). Conclusion Large - dose gamma globulin(2. 0 g/ kg,twice per day) has better clinical effect on Kawasaki disease in children than small - dose,can timely relieve the children'clinical symptoms and improve the laboratory examination results.
