实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
9期
51-53
,共3页
急性肺损伤%肺表面活性剂%婴儿,新生%疗效比较研究
急性肺損傷%肺錶麵活性劑%嬰兒,新生%療效比較研究
급성폐손상%폐표면활성제%영인,신생%료효비교연구
Acute lung injury%Pulmonary surfactants%Infant,newborn%Comparative effectiveness research
目的：比较肺表面活性物质治疗内源性与外源性新生儿急性肺损伤（ALI）的临床疗效。方法选取2014年1月—2015年1月衡水市第二人民医院收治的60例新生儿 ALI 患儿，根据病因分为内源组和外源组，每组30例。两组患儿均采用常规治疗，并联合机械通气与肺表面活性物质治疗。比较两组患儿治疗前及治疗2 h、24 h、48 h和拔管前肺顺应性、氧合指数，记录并比较两组患儿住院时间、机械通气时间和病死率。结果外源组患儿治疗前，治疗2 h、24 h、48 h 及拔管前肺顺应性均高于内源组（P <0.05）。两组患儿治疗前及拔管前氧合指数比较，差异无统计学意义（P >0.05）；外源组患儿治疗2 h、24 h、48 h 氧合指数低于内源组（P <0.05）。外源组患儿住院时间及机械通气时间均短于内源组，病死率低于内源组（P <0.05）。结论较之内源性新生儿 ALI，肺表面活性物质对外源性新生儿 ALI 的治疗效果更好，肺顺应性及氧合指数的改善效果更佳，更有利于缩短住院时间、机械通气时间。
目的：比較肺錶麵活性物質治療內源性與外源性新生兒急性肺損傷（ALI）的臨床療效。方法選取2014年1月—2015年1月衡水市第二人民醫院收治的60例新生兒 ALI 患兒，根據病因分為內源組和外源組，每組30例。兩組患兒均採用常規治療，併聯閤機械通氣與肺錶麵活性物質治療。比較兩組患兒治療前及治療2 h、24 h、48 h和拔管前肺順應性、氧閤指數，記錄併比較兩組患兒住院時間、機械通氣時間和病死率。結果外源組患兒治療前，治療2 h、24 h、48 h 及拔管前肺順應性均高于內源組（P <0.05）。兩組患兒治療前及拔管前氧閤指數比較，差異無統計學意義（P >0.05）；外源組患兒治療2 h、24 h、48 h 氧閤指數低于內源組（P <0.05）。外源組患兒住院時間及機械通氣時間均短于內源組，病死率低于內源組（P <0.05）。結論較之內源性新生兒 ALI，肺錶麵活性物質對外源性新生兒 ALI 的治療效果更好，肺順應性及氧閤指數的改善效果更佳，更有利于縮短住院時間、機械通氣時間。
목적：비교폐표면활성물질치료내원성여외원성신생인급성폐손상（ALI）적림상료효。방법선취2014년1월—2015년1월형수시제이인민의원수치적60례신생인 ALI 환인，근거병인분위내원조화외원조，매조30례。량조환인균채용상규치료，병연합궤계통기여폐표면활성물질치료。비교량조환인치료전급치료2 h、24 h、48 h화발관전폐순응성、양합지수，기록병비교량조환인주원시간、궤계통기시간화병사솔。결과외원조환인치료전，치료2 h、24 h、48 h 급발관전폐순응성균고우내원조（P <0.05）。량조환인치료전급발관전양합지수비교，차이무통계학의의（P >0.05）；외원조환인치료2 h、24 h、48 h 양합지수저우내원조（P <0.05）。외원조환인주원시간급궤계통기시간균단우내원조，병사솔저우내원조（P <0.05）。결론교지내원성신생인 ALI，폐표면활성물질대외원성신생인 ALI 적치료효과경호，폐순응성급양합지수적개선효과경가，경유리우축단주원시간、궤계통기시간。
Objective To compare the clinical effect of pulmonary surfactant on endogenous and exogenous neonatal acute lung injury. Methods A total of 60 newborns with neonatal acute lung injury were selected in the Second People's Hospital of Hengshui from January 2014 to January 2015,and they were divided into A group(with endogenous neonatal acute lung injury) and B group ( with exogenous neonatal acute lung injury) according to the etiological factor,each of 30 cases. Newborns of both groups received conventional treatment, mechanical ventilation and pulmonary surfactant. Lung compliance and oxygenation index before treatment,after 2 hours,24 hours and 48 hours of treatment,and before extubation were compared between the two groups,hospital stays,mechanical ventilation time and mortality were recorded. Results Lung compliance of B group was statistically significantly higher than that of A group at the time point before treatment,after 2 hours, 24 hours,48 hours of treatment,before extubation,respectively ( P < 0. 05 ) . No statistically significant differences of oxygenation index was found between the two group at the time point before treatment or before extubation(P > 0. 05),while oxygenation index of B group was statistically significantly lower than that of A group at the time point after 2 hours,24 hours,48 hours of treatment,respectively( P < 0. 05) . Hospital stays and mechanical ventilation time of B group were statistically significantly shorter than those of A group,and mortality of B group was statistically significantly lower than that of A group(P <0. 05). Conclusion Compared with endogenous neonatal acute lung injury,pulmonary surfactant has better clinical effect in treating exogenous neonatal acute lung injury,has better improvement effect on lung compliance and oxygenation index,is more helpful to shorten the hospital stays and mechanical ventilation time.
