中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
29期
99-100
,共2页
血流感染%血培养%降钙素原%C反应蛋白
血流感染%血培養%降鈣素原%C反應蛋白
혈류감염%혈배양%강개소원%C반응단백
Bloodstream infections%Blood culture%Procalcitonin%C-reactive protein
目的：探讨降钙素原(PCT)和C反应蛋白(CRP)在预测儿童血流感染(BSI)血培养阳性标本中的应用价值，为BSI的早期诊断和治疗提供依据。方法整群选择2013年12月—2014年12月该院急诊科收治的血培养阳性BSI患儿（观察组）和血培养阴性BSI患儿（对照组）各79例，回顾性对比分析患儿采血当日CRP、PCT结果。结果观察组患儿CRP、PCT水平显著高于对照组。以血培养结果为金标准，PCT预测的敏感度、特异度显著高于CRP (PCT、CRP对应的ROC曲线下面积分别为0.831和0.513）。观察组中革兰阴性菌感染PCT水平（50.85 ng/mL）显著高于革兰阳性菌，差异有统计学意义(P<0.05)。结论 PCT与CRP可作为检测血流感染的重要指标，联合血培养具有早期诊断细菌感染的指导意义。 PCT对BSI血培养阳性标本预测中的敏感性和特异性优于CRP，值得在临床中推广。
目的：探討降鈣素原(PCT)和C反應蛋白(CRP)在預測兒童血流感染(BSI)血培養暘性標本中的應用價值，為BSI的早期診斷和治療提供依據。方法整群選擇2013年12月—2014年12月該院急診科收治的血培養暘性BSI患兒（觀察組）和血培養陰性BSI患兒（對照組）各79例，迴顧性對比分析患兒採血噹日CRP、PCT結果。結果觀察組患兒CRP、PCT水平顯著高于對照組。以血培養結果為金標準，PCT預測的敏感度、特異度顯著高于CRP (PCT、CRP對應的ROC麯線下麵積分彆為0.831和0.513）。觀察組中革蘭陰性菌感染PCT水平（50.85 ng/mL）顯著高于革蘭暘性菌，差異有統計學意義(P<0.05)。結論 PCT與CRP可作為檢測血流感染的重要指標，聯閤血培養具有早期診斷細菌感染的指導意義。 PCT對BSI血培養暘性標本預測中的敏感性和特異性優于CRP，值得在臨床中推廣。
목적：탐토강개소원(PCT)화C반응단백(CRP)재예측인동혈류감염(BSI)혈배양양성표본중적응용개치，위BSI적조기진단화치료제공의거。방법정군선택2013년12월—2014년12월해원급진과수치적혈배양양성BSI환인（관찰조）화혈배양음성BSI환인（대조조）각79례，회고성대비분석환인채혈당일CRP、PCT결과。결과관찰조환인CRP、PCT수평현저고우대조조。이혈배양결과위금표준，PCT예측적민감도、특이도현저고우CRP (PCT、CRP대응적ROC곡선하면적분별위0.831화0.513）。관찰조중혁란음성균감염PCT수평（50.85 ng/mL）현저고우혁란양성균，차이유통계학의의(P<0.05)。결론 PCT여CRP가작위검측혈류감염적중요지표，연합혈배양구유조기진단세균감염적지도의의。 PCT대BSI혈배양양성표본예측중적민감성화특이성우우CRP，치득재림상중추엄。
Objective To explore the value of procalcitonin (PCT) and c-reactive protein (CRP) in the prediction of the re-sult of blood culture for bloodstream infection (BSI) in children so as to provide guidance for the early detection and treat-ment of this disease. Methods 79 BSI-positive children (the observation group) and 79 BSI-negative children (the control group) after blood culture who were admitted to emergency department of this hospital between December 2013 and Decem-ber 2014 were included in this study, and the levels of CRP and PCT at the time of blood collection were retrospectively analyzed. Results The levels of CRP and PCT were all higher in the observation group than in the control group. Taking blood culture results as the gold standard, the sensitivity and specificity of PCT were obviously than that of CRP, and area under the ROC curve was 0.831 and 0.513 respectively. In the observation group, the PCT level was 50.85ng/mL in patients with gram-negative infections, significantly higher than that in the patients with gram-positive infections, and the difference was statistically significant (P<0.05). Conclusion PCT and CRP can be used as the important indicators in detection of bloodstream infections, and they in combination with blood culture can provide guidance for early diagnosis of bacterial in-fection, and in this process PCT is more worthy of promotion due to its higher sensitivity and specificity over BSI.
