中国全科医学
中國全科醫學
중국전과의학
Chinese General Practice
2015年
33期
4126-4131
,共6页
高胆固醇血症Ⅱ型%诊断%治疗%进展
高膽固醇血癥Ⅱ型%診斷%治療%進展
고담고순혈증Ⅱ형%진단%치료%진전
Hyperlipoproteinemia type Ⅱ%Diagnosis%Therapy%Progress
家族性高胆固醇血症（FH）是一种常见的常染色体显性单基因遗传病，主要临床特征为血浆低密度脂蛋白胆固醇水平升高、黄色瘤、外周动脉粥样硬化和早发冠心病。该病发病率高、危害大、临床认识不足、国内诊断率较低，同时对儿童和孕妇等特殊人群临床治疗证据有限，本文结合近年来国内外对该病的诊治进展及进一步的管理策略做一综述，为临床 FH 的诊治及管理提供理论基础。
傢族性高膽固醇血癥（FH）是一種常見的常染色體顯性單基因遺傳病，主要臨床特徵為血漿低密度脂蛋白膽固醇水平升高、黃色瘤、外週動脈粥樣硬化和早髮冠心病。該病髮病率高、危害大、臨床認識不足、國內診斷率較低，同時對兒童和孕婦等特殊人群臨床治療證據有限，本文結閤近年來國內外對該病的診治進展及進一步的管理策略做一綜述，為臨床 FH 的診治及管理提供理論基礎。
가족성고담고순혈증（FH）시일충상견적상염색체현성단기인유전병，주요림상특정위혈장저밀도지단백담고순수평승고、황색류、외주동맥죽양경화화조발관심병。해병발병솔고、위해대、림상인식불족、국내진단솔교저，동시대인동화잉부등특수인군림상치료증거유한，본문결합근년래국내외대해병적진치진전급진일보적관리책략주일종술，위림상 FH 적진치급관리제공이론기출。
Familial hypercholesterolemia(FH)is a common autosomal dominant single - gene genetic disease. Its main clinical features include high plasma low - density lipoprotein cholesterol,xanthoma,peripheral artery atherosclerosis and early- onset coronary heart disease. The disease has high incidence and great harm,while there is a lack of awareness of this disease and a low diagnostic rate in China. Besides,the evidences for the clinical treatment of children and pregnant women with this disease are inadequate. The study made a review of the progress in the treatment of FH and advanced management strategies both at home and abroad and aimed to provide the oritical basis for the diagnosis,treatment and management of FH.
