中国全科医学
中國全科醫學
중국전과의학
Chinese General Practice
2015年
32期
3910-3913
,共4页
翟明明%黄丽娜%闫俊强%邵艳敏
翟明明%黃麗娜%閆俊彊%邵豔敏
적명명%황려나%염준강%소염민
脑梗死%脑血管循环%尤瑞克林%预后%相关性
腦梗死%腦血管循環%尤瑞剋林%預後%相關性
뇌경사%뇌혈관순배%우서극림%예후%상관성
Brain infarction%Cerebrovascular circulation%Urinarykallid%Prognosis%Correlation
目的:探讨脑血管反应性与尤瑞克林治疗急性脑梗死预后的相关性。方法采用随机、单盲、对照试验,选择河南科技大学第一附属医院神经内科2011年12月—2014年5月收治的194例右侧大脑中动脉供血区急性脑梗死患者,利用经颅多普勒超声(TCD)结合屏气试验检测梗死同侧大脑中动脉(MCA)的屏气指数(HBI),治疗组(89例)给予常规治疗+尤瑞克林治疗15 d,对照组(105例)给予常规治疗15 d。治疗前和治疗第16天,评估记录两组患者的美国国立卫生研究院脑卒中量表(NIHSS)评分和改良残疾程度量表(mRS)评分,分析 HBI 与 NIHSS 评分及 mRS 评分降幅的相关性。结果与治疗前比较,治疗第16天对照组和治疗组 NIHSS 评分与 mRS 评分均下降,差异有统计学意义(P ﹤0.05);治疗第16天时,对照组和治疗组 NIHSS 评分、mRS 评分比较,差异均有统计学意义(P﹤0.05)。相关性分析显示,治疗第16天时,治疗组 HBI 与 NIHSS 评分降幅、mRS 评分降幅均呈正相关(r =0.427、0.620,P ﹤0.001)。治疗第16天时,对照组 HBI 与 NIHSS 评分降幅呈正相关(r =0.618,P ﹤0.001);对照组 HBI 与mRS 评分降幅无直线相关性(r =0.191,P ﹥0.05)。结论对于急性脑梗死患者,TCD 评价下的脑血管反应性与尤瑞克林治疗急性脑梗死的短期预后呈正相关。
目的:探討腦血管反應性與尤瑞剋林治療急性腦梗死預後的相關性。方法採用隨機、單盲、對照試驗,選擇河南科技大學第一附屬醫院神經內科2011年12月—2014年5月收治的194例右側大腦中動脈供血區急性腦梗死患者,利用經顱多普勒超聲(TCD)結閤屏氣試驗檢測梗死同側大腦中動脈(MCA)的屏氣指數(HBI),治療組(89例)給予常規治療+尤瑞剋林治療15 d,對照組(105例)給予常規治療15 d。治療前和治療第16天,評估記錄兩組患者的美國國立衛生研究院腦卒中量錶(NIHSS)評分和改良殘疾程度量錶(mRS)評分,分析 HBI 與 NIHSS 評分及 mRS 評分降幅的相關性。結果與治療前比較,治療第16天對照組和治療組 NIHSS 評分與 mRS 評分均下降,差異有統計學意義(P ﹤0.05);治療第16天時,對照組和治療組 NIHSS 評分、mRS 評分比較,差異均有統計學意義(P﹤0.05)。相關性分析顯示,治療第16天時,治療組 HBI 與 NIHSS 評分降幅、mRS 評分降幅均呈正相關(r =0.427、0.620,P ﹤0.001)。治療第16天時,對照組 HBI 與 NIHSS 評分降幅呈正相關(r =0.618,P ﹤0.001);對照組 HBI 與mRS 評分降幅無直線相關性(r =0.191,P ﹥0.05)。結論對于急性腦梗死患者,TCD 評價下的腦血管反應性與尤瑞剋林治療急性腦梗死的短期預後呈正相關。
목적:탐토뇌혈관반응성여우서극림치료급성뇌경사예후적상관성。방법채용수궤、단맹、대조시험,선택하남과기대학제일부속의원신경내과2011년12월—2014년5월수치적194례우측대뇌중동맥공혈구급성뇌경사환자,이용경로다보륵초성(TCD)결합병기시험검측경사동측대뇌중동맥(MCA)적병기지수(HBI),치료조(89례)급여상규치료+우서극림치료15 d,대조조(105례)급여상규치료15 d。치료전화치료제16천,평고기록량조환자적미국국립위생연구원뇌졸중량표(NIHSS)평분화개량잔질정도량표(mRS)평분,분석 HBI 여 NIHSS 평분급 mRS 평분강폭적상관성。결과여치료전비교,치료제16천대조조화치료조 NIHSS 평분여 mRS 평분균하강,차이유통계학의의(P ﹤0.05);치료제16천시,대조조화치료조 NIHSS 평분、mRS 평분비교,차이균유통계학의의(P﹤0.05)。상관성분석현시,치료제16천시,치료조 HBI 여 NIHSS 평분강폭、mRS 평분강폭균정정상관(r =0.427、0.620,P ﹤0.001)。치료제16천시,대조조 HBI 여 NIHSS 평분강폭정정상관(r =0.618,P ﹤0.001);대조조 HBI 여mRS 평분강폭무직선상관성(r =0.191,P ﹥0.05)。결론대우급성뇌경사환자,TCD 평개하적뇌혈관반응성여우서극림치료급성뇌경사적단기예후정정상관。
Objective To investigate the correlation between cerebrovascular reactivity and the prognosis of patients with acute cerebral infarction treated by urinarykallid. Methods In this randomized,single - blind and control study,we enrolled 194 patients with acute cerebral infarction in arterial blood supply area of right brain who were admitted into the Department of Neurology of the First Affiliated Hospital of He'nan University of Science and Technology from December 2011 to May 2014. Breath - holding index( HBI)of the middle cerebral artery( MCA)in the brain hemisphere with infarction was measured using transcranial doppler sonography( TCD)and breath - holding test. Treatment group( n = 89 ) was given conventional therapy combined with urinarykallid for 15 days,and control group(n = 105)was given conventional treatment for 15 days. Before treatment and 16 days after treatment,we recorded NIHSS and mRS scores of the two groups,and the correlation between HBI and the scores was analyzed. Results The two groups had lower(P ﹤ 0. 05)scores of NIHSS and mRS on 16 days after treatment than before treatment;16 days after treatment,the two groups were significantly different(P ﹤ 0. 05) in the scores of NIHSS and mRS scores. The correlation analysis showed that,on 16 days during treatment,HBI was positively correlated with reduction of NIHSS and mRS scores in treatment group(r = 0. 427,0. 620,P ﹤ 0. 001);on 16 days during treatment,HBI was positively correlated with reduction of NIHSS scores in control group(r = 0. 618,P ﹤ 0. 001),and HBI had no linear correlation with reduction of mRS scores(r = 0. 191,P ﹥ 0. 05). Conclusion For patients with acute cerebral infarction,there is positive correlation between the vascular reactivity evaluated by TCD and short - term prognosis of patients treated by urinarykallid.