CAJ | 학술논문

目的：对比分析不同剂量腺苷蛋氨酸治疗病毒性肝炎的疗效。方法选取该院2013年7月—2014年7月期间收治的90例病毒性肝炎患者作为研究对象，随机分为A组和B组，每组各45例，A组45例患者予以1000 mg/d的腺苷蛋氨酸进行治疗，B组45例患者予以2000 mg/d腺苷蛋氨酸进行治疗，对于两组中出现的重症患者，均辅以其它护肝等对症治疗，对比观察不同剂量腺苷蛋氨酸治疗病毒性肝炎的的临床效果和不良反应。结果治疗后A组和B组ALT、AST、Alb、TBil、TBA、ALP、GGT、PT指标均有所改善，B组ALT、AST、TBil下降程度与A组比较，差异有统计学意义（P<0.05）。两组患者未出现不良反应。结论大剂量的腺苷蛋氨酸治疗病毒性肝炎比小剂量效果更明显，且安全性较高。
목적：대비분석불동제량선감단안산치료병독성간염적료효。방법선취해원2013년7월—2014년7월기간수치적90례병독성간염환자작위연구대상，수궤분위A조화B조，매조각45례，A조45례환자여이1000 mg/d적선감단안산진행치료，B조45례환자여이2000 mg/d선감단안산진행치료，대우량조중출현적중증환자，균보이기타호간등대증치료，대비관찰불동제량선감단안산치료병독성간염적적림상효과화불량반응。결과치료후A조화B조ALT、AST、Alb、TBil、TBA、ALP、GGT、PT지표균유소개선，B조ALT、AST、TBil하강정도여A조비교，차이유통계학의의（P<0.05）。량조환자미출현불량반응。결론대제량적선감단안산치료병독성간염비소제량효과경명현，차안전성교고。
Objective To observe and compare the efficacy of different doses of ademetionine for the treatment of viral hepatitis. Methods Ninety cases with viral hepatitis admitted in our hospital from July 2013 to July 2014 were selected as the subjects and randomly divided into group A and group B with 45 cases in each. Patients in group A were treated by 1 000 mg ademetionine per day, and those in group B were treated by 2 000 mg ademetionine per day. The severe patients in the two groups were given protection of liver and other symptomatic treatment additionally. And the clinical effect and incidence of adverse reactions of the two groups were observed and compared. Results After treatment, the values of ALT, AST, Alb, TBil, TBA, ALP, GGT and PT improved in both groups. The differences in the reduction of the values of ALT, AST and TBil between group A and group B were statistically significant, P<0.05. No adverse reactions occurred in both groups. Conclusion Large dose of ademetionine has more significant effect on viral hepatitis than small dose of ademetion-ine with higher safety.