实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
2015年
9期
108-110
,共3页
肺源性心脏病%丹参川芎嗪注射液%前列地尔注射液%血液流变学
肺源性心髒病%丹參川芎嗪註射液%前列地爾註射液%血液流變學
폐원성심장병%단삼천궁진주사액%전렬지이주사액%혈액류변학
Pulmonary heart disease%Danshen ligustrazine injection%Alprostadil injection%Hemorheology
目的：探讨丹参川芎嗪注射液联合前列地尔注射液治疗慢性肺源性心脏病（肺心病）急性加重期的临床疗效。方法选取2014年1月—2015年4月西北工业大学医院收治的140例慢性肺心病急性加重期患者，按照随机数字表法分为对照组和观察组，每组70例。两组患者均给予常规治疗，观察组患者给予丹参川芎嗪注射液联合前列地尔注射液治疗，对照组患者仅给予前列地尔注射液治疗；两组患者均治疗2周。比较两组患者临床疗效，治疗前后心功能指标〔左心室射血分数（LVEF）、心排血量（CO）〕及血液流变学指标（全血高切黏度、全血低切黏度、血浆黏度、红细胞最大聚集指数、血细胞比容）。结果观察组患者临床疗效优于对照组（u =-3.47，P <0.05）。治疗前两组患者 LVEF、CO 比较，差异无统计学意义（P >0.05）；治疗后观察组患者 LVEF、CO 均高于对照组（P <0.05）。治疗前两组患者全血高切黏度、全血低切黏度、血浆黏度、红细胞最大聚集指数、血细胞比容比较，差异无统计学意义（P >0.05）；治疗后观察组患者全血高切黏度、全血低切黏度、血浆黏度、红细胞最大聚集指数、血细胞比容均低于对照组（P <0.05）。结论丹参川芎嗪注射液联合前列地尔注射液治疗慢性肺心病急性加重期的临床疗效确切，能有效改善患者心功能及血液流变学。
目的：探討丹參川芎嗪註射液聯閤前列地爾註射液治療慢性肺源性心髒病（肺心病）急性加重期的臨床療效。方法選取2014年1月—2015年4月西北工業大學醫院收治的140例慢性肺心病急性加重期患者，按照隨機數字錶法分為對照組和觀察組，每組70例。兩組患者均給予常規治療，觀察組患者給予丹參川芎嗪註射液聯閤前列地爾註射液治療，對照組患者僅給予前列地爾註射液治療；兩組患者均治療2週。比較兩組患者臨床療效，治療前後心功能指標〔左心室射血分數（LVEF）、心排血量（CO）〕及血液流變學指標（全血高切黏度、全血低切黏度、血漿黏度、紅細胞最大聚集指數、血細胞比容）。結果觀察組患者臨床療效優于對照組（u =-3.47，P <0.05）。治療前兩組患者 LVEF、CO 比較，差異無統計學意義（P >0.05）；治療後觀察組患者 LVEF、CO 均高于對照組（P <0.05）。治療前兩組患者全血高切黏度、全血低切黏度、血漿黏度、紅細胞最大聚集指數、血細胞比容比較，差異無統計學意義（P >0.05）；治療後觀察組患者全血高切黏度、全血低切黏度、血漿黏度、紅細胞最大聚集指數、血細胞比容均低于對照組（P <0.05）。結論丹參川芎嗪註射液聯閤前列地爾註射液治療慢性肺心病急性加重期的臨床療效確切，能有效改善患者心功能及血液流變學。
목적：탐토단삼천궁진주사액연합전렬지이주사액치료만성폐원성심장병（폐심병）급성가중기적림상료효。방법선취2014년1월—2015년4월서북공업대학의원수치적140례만성폐심병급성가중기환자，안조수궤수자표법분위대조조화관찰조，매조70례。량조환자균급여상규치료，관찰조환자급여단삼천궁진주사액연합전렬지이주사액치료，대조조환자부급여전렬지이주사액치료；량조환자균치료2주。비교량조환자림상료효，치료전후심공능지표〔좌심실사혈분수（LVEF）、심배혈량（CO）〕급혈액류변학지표（전혈고절점도、전혈저절점도、혈장점도、홍세포최대취집지수、혈세포비용）。결과관찰조환자림상료효우우대조조（u =-3.47，P <0.05）。치료전량조환자 LVEF、CO 비교，차이무통계학의의（P >0.05）；치료후관찰조환자 LVEF、CO 균고우대조조（P <0.05）。치료전량조환자전혈고절점도、전혈저절점도、혈장점도、홍세포최대취집지수、혈세포비용비교，차이무통계학의의（P >0.05）；치료후관찰조환자전혈고절점도、전혈저절점도、혈장점도、홍세포최대취집지수、혈세포비용균저우대조조（P <0.05）。결론단삼천궁진주사액연합전렬지이주사액치료만성폐심병급성가중기적림상료효학절，능유효개선환자심공능급혈액류변학。
Objective To investigate the clinical effect of danshen ligustrazine injection combined with alprostadil injection on acute exacerbation of chronic pulmonary heart disease. Methods A total of 140 patients with acute exacerbation of chronic pulmonary heart disease admitted to Hospital of Northwestern Polytechnical University from January 2014 to April 2015 were selected,and they were divided into control group and observation group according to random number table,each of 70 cases. Based on conventional treatment,patients of control group were given extra alprostadil injection,while patients of observation group were given extra danshen ligustrazine injection combined with alprostadil injection,both groups treated for 2 weeks. Clinical effect,cardiac function index(including LVEF and CO)and hemodynamic index(including whole high blood viscosity,whole low blood viscosity,plasma viscosity,erythrocyte maximal aggregation index and hematokrit)before and after treatment were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group( u = - 3. 47,P < 0. 05). No statistically significant differences of LVEF or CO was found between the two groups before treatment( P > 0. 05),while LVEF and CO of observation group were statistically significantly higher than those of control group after treatment( P < 0. 05). No statistically significant differences of whole high blood viscosity,whole low blood viscosity,plasma viscosity,erythrocyte maximal aggregation index or hematokrit was found between the two groups before treatment( P > 0. 05),while whole high blood viscosity,whole low blood viscosity,plasma viscosity, erythrocyte maximal aggregation index and hematokrit of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05). Conclusion Danshen ligustrazine injection combined with alprostadil injection has certain clinical effect in treating acute exacerbation of chronic pulmonary heart disease,can effectively improve the cardiac function and hemorheology.
