CAJ | 학술논문

P－GP作为一种能量依赖性膜转运蛋白，高表达于具有屏障和分泌功能的器官中。在脑组织中，主要表达于血脑屏障的脑血管内皮细胞上。脑损伤疾病（如癫痫和脑缺血）状态下，P－GP在大鼠大脑的海马区、皮质和纹状体上均出现表达，细胞定位主要存在于脑血管内皮细胞上，在神经元和胶质细胞上也存在过表达现象。
P－GP작위일충능량의뢰성막전운단백，고표체우구유병장화분비공능적기관중。재뇌조직중，주요표체우혈뇌병장적뇌혈관내피세포상。뇌손상질병（여전간화뇌결혈）상태하，P－GP재대서대뇌적해마구、피질화문상체상균출현표체，세포정위주요존재우뇌혈관내피세포상，재신경원화효질세포상야존재과표체현상。
As an energy dependent membrane transporter, P-GP highly expresses in the organs which have the function of barrier and secretory.In the brain, P-GP mainly expresses in the cerebral vascular endothelial cells of blood brain barrier.In the state of brain injury diseases ( such as epilepsy and cerebral ischemia) , P-GP appears in the hippocampus, cortex and striatum of rat brain.At cellular level, it mainly exists in the cerebral vascular endo-thelial cells and also overexpresses in the neurons and glial cells.