基础医学与临床
基礎醫學與臨床
기출의학여림상
Basic & Clinical Medicine
2015年
10期
1414-1418
,共5页
PTEN%肿瘤抑制因子%PI3K/AKT信号通路%肿瘤
PTEN%腫瘤抑製因子%PI3K/AKT信號通路%腫瘤
PTEN%종류억제인자%PI3K/AKT신호통로%종류
PTEN%tumour suppressor%PI3K-Akt/PKB pathway%cancer
抑癌基因PTEN的缺失和突变常常和肿瘤的发生发展密切相关。而除了基因的缺失和突变，PTEN也受到许多非基因机制的调控，如转录调控、表观沉默、非编码RNA的转录后调控、翻译后修饰。
抑癌基因PTEN的缺失和突變常常和腫瘤的髮生髮展密切相關。而除瞭基因的缺失和突變，PTEN也受到許多非基因機製的調控，如轉錄調控、錶觀沉默、非編碼RNA的轉錄後調控、翻譯後脩飾。
억암기인PTEN적결실화돌변상상화종류적발생발전밀절상관。이제료기인적결실화돌변，PTEN야수도허다비기인궤제적조공，여전록조공、표관침묵、비편마RNA적전록후조공、번역후수식。
Mutations and deletions of the tumour suppressor PTEN are frequently involved in the development of cancer.However, PTEN is also tightly controlled by various non-genomic mechanisms,such as the epigenetic silen-cing of PTEN, post-transcriptional regulation by non-coding RNAs and post-translational modification.
