CAJ | 학술논문

外泌体是多种活细胞主动向胞外分泌的囊泡样小体。蛋白质组学是在蛋白质水平上研究关于疾病发生、细胞代谢等过程的一门系统生物学。以蛋白质组学技术平台研究肿瘤细胞来源或与之相关的外泌体，在阐明外泌体在形成和维持肿瘤细胞存活、增殖和转移侵袭的微环境，诱导肿瘤细胞增殖等方面的机制和发现肿瘤生物标志物方面等取得了一些进步，使得外泌体在临床诊疗中的应用展现出良好前景。
외비체시다충활세포주동향포외분비적낭포양소체。단백질조학시재단백질수평상연구관우질병발생、세포대사등과정적일문계통생물학。이단백질조학기술평태연구종류세포래원혹여지상관적외비체，재천명외비체재형성화유지종류세포존활、증식화전이침습적미배경，유도종류세포증식등방면적궤제화발현종류생물표지물방면등취득료일사진보，사득외비체재림상진료중적응용전현출량호전경。
Exosomes are vesicles of endocytic origin released from different cell types under both normal and pathological conditions.Proteomics is an emerging discipline for studying composition and mechanics and interac-tion of proteins with regard to disease occurrence、cellular metabolism,etc.Progress of research on exosomes from tumor cell at proteomics technology platforms in aspect of clarifying mechanisms of shaping and sustaining micro-enviroment of tumor growth and survival and metastasis, induce tumor proliferation, Immunosuppressive effects or immune evasion, and discovering biomarker, makes a promising prospect of exsomes in clinical diagnosis and treatment.