CAJ | 학술논문

食用槟榔在南亚和东南亚以及环太平洋地区的岛屿非常普遍，在中国亦有蔓延扩大的趋势。槟榔咀嚼块一般由槟榔、烟草、槟榔叶、蒌叶、花序和熟石灰以及一些特殊的调味剂组成，不同国家和地区的槟榔咀嚼块的组成及加工方法不一，但槟榔和烟草等是槟榔咀嚼块中最主要的组成部分。食用槟榔是导致口腔黏膜下纤维化的最主要原因，可增加口腔癌发病率且与口腔白斑和口腔扁平苔藓等癌前病变密切相关。食用槟榔之所以会导致口腔癌，是因为槟榔中的多种活性成分和代谢产物有细胞毒性、遗传毒性甚至直接致癌性，这些物质包括槟榔生物碱、槟榔鞣质、槟榔特异性亚硝胺和活性氧等。本文就食用槟榔的流行情况，食用槟榔的成分和致癌机制，食用槟榔与口腔癌前病变和口腔癌的关系等研究进展作一综述，旨在为做好食用槟榔引发的口腔相关病变风险程度的评价提供参考，为口腔癌的预防和宣教提供科学依据。
식용빈랑재남아화동남아이급배태평양지구적도서비상보편，재중국역유만연확대적추세。빈랑저작괴일반유빈랑、연초、빈랑협、루협、화서화숙석회이급일사특수적조미제조성，불동국가화지구적빈랑저작괴적조성급가공방법불일，단빈랑화연초등시빈랑저작괴중최주요적조성부분。식용빈랑시도치구강점막하섬유화적최주요원인，가증가구강암발병솔차여구강백반화구강편평태선등암전병변밀절상관。식용빈랑지소이회도치구강암，시인위빈랑중적다충활성성분화대사산물유세포독성、유전독성심지직접치암성，저사물질포괄빈랑생물감、빈랑유질、빈랑특이성아초알화활성양등。본문취식용빈랑적류행정황，식용빈랑적성분화치암궤제，식용빈랑여구강암전병변화구강암적관계등연구진전작일종술，지재위주호식용빈랑인발적구강상관병변풍험정도적평개제공삼고，위구강암적예방화선교제공과학의거。
?Betel-quid?chewing?is?common?in?South?Asia,?South-east?Asia,?and?the?Pacific?Islands,?especially?in?our?country.?Betel-quid?contains?various?ingredients,?including?areca-nut,?tobacco,?betel?leaf,?betel?vine,?inflorescence,?slaked?lime,?and?some?special?flavored?substances.?The?composition?and?processing?of?betel-quid?vary?in?different?countries.?However,?areca-nut?and?tobacco?are?consistent?main?components.?Areca-nut?contains?betel?alkaloid,?tannin?betel?nut,?betel?nut-specific?nitrosamines,?and?reactive?oxygen,?which?exerts?cytotoxic,?genotoxic,?and?carcinogen?effects.?Previous?studies?showed?that?betel-quid?chewing?is?a?significant?factor?contributing?to?oral?submucous?fibrosis?and?is?related?to?the?incidence?of?oral?cancer,?leukoplakia,?lichen?planus,?and?so?on.?This?paper?presents?the?prevalence?of?areca-nut?consumption,?ingredients,?and?carcinogenic?mechanism?to?provide?a?scientific?basis?for?oral?cancer?prevention?and?awareness.