CAJ | 학술논문

目的：观察阿托伐他汀对血脂正常的原发性高血压患者ankle-brachial index(ABI)及homocysteine(HCY)影响。方法血脂正常的原发性高血压患者130例随机分为对照组（n=63）和治疗组（n=67，阿托伐他汀20mg，每晚1次），疗程均为6个月。入选前所有患者经服用降压药物后血压控制在140/90mmHg以下至少4周，观察ABI、HCY在治疗前后的变化。结果治疗6月末时，阿托伐他汀组治疗6月前后，ABI、HCY均有统计学差异（均P＜0.05）。对照组治疗前后ABI、HCY的差异均无统计学意义（P>0.05）。结论阿托伐他汀可升高ABI，降低HCY，改善原发性高血压患者发生心脑血管疾病并发症的风险。
목적：관찰아탁벌타정대혈지정상적원발성고혈압환자ankle-brachial index(ABI)급homocysteine(HCY)영향。방법혈지정상적원발성고혈압환자130례수궤분위대조조（n=63）화치료조（n=67，아탁벌타정20mg，매만1차），료정균위6개월。입선전소유환자경복용강압약물후혈압공제재140/90mmHg이하지소4주，관찰ABI、HCY재치료전후적변화。결과치료6월말시，아탁벌타정조치료6월전후，ABI、HCY균유통계학차이（균P＜0.05）。대조조치료전후ABI、HCY적차이균무통계학의의（P>0.05）。결론아탁벌타정가승고ABI，강저HCY，개선원발성고혈압환자발생심뇌혈관질병병발증적풍험。
Objective To observe the effect of atorvastatin on the serum homocysteine and ankle brachial index(ABI) in essen-tial hypertensives with normal lipidemia. Methods One hundred and thirty essential hypertensives with normal lipidemia regularly taking anti-hypertension drugs were randomly divided into control group (n=63) and atorvastatin group (n=67) and treated for 6 months. ABI and HCY were measured before and after treatment. Results No change of all measurements in control group was found after treatment. In atorvastatin group,however,ABI is increased,HCY is decreased (P<0.05). Conclusions Atorvastatin can rise ABI,reduce HCY,improve risk of complication in hypertensives.