中国医药
中國醫藥
중국의약
China Medicine
2015年
11期
1577-1579
,共3页
郭俊晓%张玉龙%刘志平%赵龙
郭俊曉%張玉龍%劉誌平%趙龍
곽준효%장옥룡%류지평%조룡
先天性心脏病%肺动脉高压%脑钠肽%氨基末端脑钠肽前体
先天性心髒病%肺動脈高壓%腦鈉肽%氨基末耑腦鈉肽前體
선천성심장병%폐동맥고압%뇌납태%안기말단뇌납태전체
Congenital heart disease%Pulmonary arterial hypertension%Brain natriuretic peptide%Amino-terminal pro-brain natriuretic peptide
目的 分析先天性心脏病伴不同程度肺动脉高压(PAH)患儿血浆脑钠肽(BNP)及氨基末端脑钠肽前体(NT-proBNP)水平的变化情况.方法 纳入2012年12月至2013年12月内蒙古医科大学附属医院经超声心动图确诊的左向右分流先天性心脏病患儿60例.采用超声心动图评估肺动脉收缩压,比较不同程度PAH患儿血浆BNP及NT-proBNP水平差异.结果 无PAH患儿16例、轻度PAH患儿16例、中度PAH患儿14例、重度PAH患儿14例.血浆BNP及NT-proBNP水平在无PAH、轻度PAH、中度PAH和重度PAH患儿中依次升高[BNP: (30 ±26)、(134 ±22)、(307±86)、(661±67) ng/L;NT-proBNP:(94±35)、(153 ±25)、(487 ±213)、(2 430±1 278) ng/L],其中血浆BNP无PAH,轻度、中度、重度PAH患儿间两两比较差异均有统计学意义(均P＜0.05),NT-proBNP仅重度PAH患儿与无PAH患儿间差异有统计学意义(P＜0.05),余不同程度PAH患儿间差异无统计学意义(均P＞0.05).结论 左向右分流先天性心脏病患儿血浆BNP及NT-proBNP水平随PAH严重程度的增加而逐渐升高,可作为评价PAH严重程度的指标.
目的 分析先天性心髒病伴不同程度肺動脈高壓(PAH)患兒血漿腦鈉肽(BNP)及氨基末耑腦鈉肽前體(NT-proBNP)水平的變化情況.方法 納入2012年12月至2013年12月內矇古醫科大學附屬醫院經超聲心動圖確診的左嚮右分流先天性心髒病患兒60例.採用超聲心動圖評估肺動脈收縮壓,比較不同程度PAH患兒血漿BNP及NT-proBNP水平差異.結果 無PAH患兒16例、輕度PAH患兒16例、中度PAH患兒14例、重度PAH患兒14例.血漿BNP及NT-proBNP水平在無PAH、輕度PAH、中度PAH和重度PAH患兒中依次升高[BNP: (30 ±26)、(134 ±22)、(307±86)、(661±67) ng/L;NT-proBNP:(94±35)、(153 ±25)、(487 ±213)、(2 430±1 278) ng/L],其中血漿BNP無PAH,輕度、中度、重度PAH患兒間兩兩比較差異均有統計學意義(均P＜0.05),NT-proBNP僅重度PAH患兒與無PAH患兒間差異有統計學意義(P＜0.05),餘不同程度PAH患兒間差異無統計學意義(均P＞0.05).結論 左嚮右分流先天性心髒病患兒血漿BNP及NT-proBNP水平隨PAH嚴重程度的增加而逐漸升高,可作為評價PAH嚴重程度的指標.
목적 분석선천성심장병반불동정도폐동맥고압(PAH)환인혈장뇌납태(BNP)급안기말단뇌납태전체(NT-proBNP)수평적변화정황.방법 납입2012년12월지2013년12월내몽고의과대학부속의원경초성심동도학진적좌향우분류선천성심장병환인60례.채용초성심동도평고폐동맥수축압,비교불동정도PAH환인혈장BNP급NT-proBNP수평차이.결과 무PAH환인16례、경도PAH환인16례、중도PAH환인14례、중도PAH환인14례.혈장BNP급NT-proBNP수평재무PAH、경도PAH、중도PAH화중도PAH환인중의차승고[BNP: (30 ±26)、(134 ±22)、(307±86)、(661±67) ng/L;NT-proBNP:(94±35)、(153 ±25)、(487 ±213)、(2 430±1 278) ng/L],기중혈장BNP무PAH,경도、중도、중도PAH환인간량량비교차이균유통계학의의(균P＜0.05),NT-proBNP부중도PAH환인여무PAH환인간차이유통계학의의(P＜0.05),여불동정도PAH환인간차이무통계학의의(균P＞0.05).결론 좌향우분류선천성심장병환인혈장BNP급NT-proBNP수평수PAH엄중정도적증가이축점승고,가작위평개PAH엄중정도적지표.
Objective To explore the changes of plasma brain natriuretic peptide (BNP) and aminoterminal pro-brain natriuretic peptide (NT-proBNP) in children with congenital heart disease (CHD) complicated with different degrees of pulmonary arterial hypertension (PAH).Methods Totally 60 children of left-right shunt congenital heart disease from December 2012 to December 2013 were enrolled.The pulnonary arterial systolic pressure was measured by echocardiography;the BNP and NT-proBNP level were measured and compared among patients with different degree of PAH.Results The plasma BNP and NT-proBNP were increased in non PAH, mild PAH, moderate PAH and severe PAH patients [(30 ± 26), (134 ± 22), (307 ± 86), (661 ± 67) ng/L;(94 ±35), (153 ± 25), (487 ± 213), (2 430 ± 1 278) ng/L].There were significant differences regarding plasma BNP among non PAH, mild PAH, moderate PAH and severe PAH patients (all P ＜ 0.05);NT-proBNP showed statistical differences in severe PAH patients compared with that in non-PAH patients (P ＜ 0.05) and no differences were observed among other patients (all P ＞ 0.05).Conclusion In left to right shunt congenital heart disease children complicated with PAH, the plasma BNP and NT-proBNP levels increased with increasing of PAH degree, and can be used as an index to evaluate the degrees of PAH.
