CAJ | 학술논문

在乳恒牙交替过程中，乳牙不断脱落，即脱落乳牙牙髓干细胞（SHED）获取容易，且SHED较骨髓间质干细胞和牙髓干细胞有更强的细胞增殖能力。SHED含有的成纤维细胞生长因子、转化生长因子-β、结缔组织生长因子、神经生长因子、骨形态发生蛋白等促进SHED增殖。SHED可向成牙本质细胞、神经细胞、软骨细胞、脂肪细胞和肝细胞向分化及诱导宿主细胞分化为成骨细胞，还有免疫调节和促进伤口愈合功能，是理想的骨组织工程和皮肤组织工程种子细胞。有鉴于此，SHED在治疗牙体缺失、骨缺损，神经系统疾病和免疫系统疾病，皮肤外伤和肝脏疾病方面有着广泛的应用前景。
재유항아교체과정중，유아불단탈락，즉탈락유아아수간세포（SHED）획취용역，차SHED교골수간질간세포화아수간세포유경강적세포증식능력。SHED함유적성섬유세포생장인자、전화생장인자-β、결체조직생장인자、신경생장인자、골형태발생단백등촉진SHED증식。SHED가향성아본질세포、신경세포、연골세포、지방세포화간세포향분화급유도숙주세포분화위성골세포，환유면역조절화촉진상구유합공능，시이상적골조직공정화피부조직공정충자세포。유감우차，SHED재치료아체결실、골결손，신경계통질병화면역계통질병，피부외상화간장질병방면유착엄범적응용전경。
?Deciduous?teeth?are?constantly?exfoliated?in?the?alternate?process?of?deciduous?and?permanent?teeth.?Hence,?obtaining?stem?cells?from?human-exfoliated?deciduous?teeth(SHED)?is?simple?and?convenient.?The?proliferation?rate?of?SHED?was?significantly?higher?than?that?of?dental?pulp?stem?cells?and?bone?marrow?mesenchymal?stem?cells.?SHED?expressed several growth factors for promoting proliferation, such as fibroblast growth factor, transforming growth factor-β, connective?tissue?growth?factor,?nerve?growth?factor,?and?bone?morphogenetic?protein.?SHED?are?able?to?differentiate?into?odontoblasts,?neural?cells,?cartilage?cells,?adipocytes,?and?liver?cells,?and?can?induce?host?cells?to?regenerate?bone.?In?addition,?SHED?have?immune?modulatory?effects?and?can?enhance?wound-healing?effects.?SHED?are?ideal?seed?cells?for?bone?and?skin?tissue?engineering.?Thus,?SHED?can?potentially?be?used?for?treating?tooth?and?bone?defects,?nervous?system?diseases,?immune?system?diseases,?skin?trauma,?and?liver?diseases.