CAJ | 학술논문

微生物代谢组学诞生于1992年，其研究一般包括样本采集、样本检测和数据分析。早期，微生物代谢组学主要用于不同菌株特性的生物学鉴定；目前，代谢组学技术已应用于微生物表型分类、突变体筛选，代谢途径和微生物代谢工程，发酵工程监控和优化，微生物环境污染物等方面。在口腔医学领域，微生物代谢组学技术在微生物鉴定以及龋病、牙周病、唇腭裂和口腔肿瘤研究中皆有应用，最多的还是用于口腔中的致龋菌和牙周致病菌代谢产物的分析。微生物代谢组学技术可以很好地检测出不同菌株间的差异，因而有望成为口腔微生物快速鉴定的新技术。本文就微生物代谢组学的研究策略及应用进展作一综述并提出未来研究中面临的难题。
미생물대사조학탄생우1992년，기연구일반포괄양본채집、양본검측화수거분석。조기，미생물대사조학주요용우불동균주특성적생물학감정；목전，대사조학기술이응용우미생물표형분류、돌변체사선，대사도경화미생물대사공정，발효공정감공화우화，미생물배경오염물등방면。재구강의학영역，미생물대사조학기술재미생물감정이급우병、아주병、진악렬화구강종류연구중개유응용，최다적환시용우구강중적치우균화아주치병균대사산물적분석。미생물대사조학기술가이흔호지검측출불동균주간적차이，인이유망성위구강미생물쾌속감정적신기술。본문취미생물대사조학적연구책략급응용진전작일종술병제출미래연구중면림적난제。
?Microbial?metabolomics?began?in?1992,?and?research?on?this?field?includes?sample?collection,?sample?testing,?and?data?analysis.?Early?microbial?metabolomics?is?mainly?utilized?for?the?biological?identification?and?characterization?of?different?strains.?At?present,?metabolomics?has?been?applied?to?microbial?phenotypic?classification,?mutant?screening,?metabolic?pathway?and?metabolic?engineering,?control?and?optimization?of?fermentation?engineering?and?microbial?contaminants,?and?so?on.?In?dentistry,?microbial?metabolomics?technology?has?been?applied?in?microbial?identification,?dental?caries,?periodontal?disease?and?oral?cancer,?and?cleft?lip?and?palate.?Analysis?of?cariogenic?bacteria?and?perio-dontal?pathogen?metabolites?in?the?oral?cavity?is?a?common?practice.?Given?its?accuracy?in?differentiating?different?strains,?microbial?metabolomics?technology?is?expected?to?become?a?new?technique?for?the?rapid?identification?of?oral?microorganisms.?This?paper?reviews?the?progress?in?the?study?of?microbial?strategies?and?applications?of?metabolomics?and?presents?the?problems?that?may?be?faced?in?future?studies.