CAJ | 학술논문

细胞外信号调节激酶（ERK）信号转导通路广泛调控牙发生及其形态发育，且其作用伴随在牙发生的各个时期。成纤维细胞生长因子-10通过激活牙上皮细胞中的ERK信号转导通路促进牙胚发生发育。在间质细胞的牙向分化以及牙周组织的发生和分化过程中，ERK信号转导通路皆起着重要的作用。三氧化聚合物可通过磷酸化激活ERK，从而诱导牙质细胞分化。ERK信号转导通路对于牙髓干细胞（DPSC）向成牙质细胞的分化很重要，激活DPSC中的ERK信号转导通路对成牙质细胞的再生是一条有效途径。在牙发生过程中，机械压力可诱导间质细胞向成骨细胞分化；反之，机械拉力则通过增强ERK磷酸化促进DPSC增殖，抑制其向成骨细胞分化。ERK信号转导通路既有利于DPSC迁移，也有利于牙髓组织重建。本文就ERK信号转导通路在牙发生过程中的作用作一综述，以探讨其对牙再生的影响。
세포외신호조절격매（ERK）신호전도통로엄범조공아발생급기형태발육，차기작용반수재아발생적각개시기。성섬유세포생장인자-10통과격활아상피세포중적ERK신호전도통로촉진아배발생발육。재간질세포적아향분화이급아주조직적발생화분화과정중，ERK신호전도통로개기착중요적작용。삼양화취합물가통과린산화격활ERK，종이유도아질세포분화。ERK신호전도통로대우아수간세포（DPSC）향성아질세포적분화흔중요，격활DPSC중적ERK신호전도통로대성아질세포적재생시일조유효도경。재아발생과정중，궤계압력가유도간질세포향성골세포분화；반지，궤계랍력칙통과증강ERK린산화촉진DPSC증식，억제기향성골세포분화。ERK신호전도통로기유리우DPSC천이，야유리우아수조직중건。본문취ERK신호전도통로재아발생과정중적작용작일종술，이탐토기대아재생적영향。
Extracellular?signal-regulated?kinase(ERK)?is?an?important?signaling?transduction?pathway?involved?in?tooth?development.?The?pathway?widely?regulates?dentification?and?tooth?morphogenesis?in?each?developmental?stage.?Fibroblast?growth?factor-10?promotes?the?initiation?and?development?of?tooth?germ?by?activating?the?ERK?signaling?transduction?pathway?in?dental?epithelium.?The?pathway?also?regulates?the?differentiation?of?mesenchymal?stem?cells?into?odontoblasts?and?the?initiation?and?differentiation?of?periodontium.?Mineral?trioxide?aggregate?can?induce?odontoblast?differentiation?by?phosphorylating?and?activating?ERK.?The?pathway?is?critical?in?inducing?the?differentiation?of?dental?pulp?stem?cell(DPSC)?into?odontoblasts;?hence,?activating?the?ERK?signaling?pathway?in?DPSC?may?be?an?effective?way?to?regenerate?odontoblasts.?Hydrostatic?pressures?during?dentification?promote?mesenchymal?osteodifferentiation.?By?contrast,?mechanical?stretch?inhibits?osteogenic?differentiation?by?increasing?pERK-mediated?cell?proliferation.?The?ERK?signaling?pathway?facilitates?the?migration?of?DPSC?and?the?regeneration?of?dental?pulp?tissue.?This?review?enumerates?the?functions?of?the?ERK?pathway?in?dentification?and?discusses?how?ERK?influences?tooth?regeneration.