CAJ | 학술논문

牙周炎可能是早产、子痫前期以及胎儿生长受限和低体质量儿不良妊娠的危险因素，二者在病理生理学基础上的相关性主要来自宿主对疾病产生的炎症反应和免疫应答。并非所有牙周炎都会引起不良妊娠，这一发现引发了学者对这两种疾病遗传学的研究。与上述炎症反应和免疫应答相关的某些细胞因子和受体的基因多态性，可作为衡量这两种疾病易患性和严重程度的指标。本文从遗传多态性方面进一步探讨孕妇牙周炎与不良妊娠之间的作用机制，以确定其高危致病基因并进行联合筛查，为预防和临床治疗提供新信息。
아주염가능시조산、자간전기이급태인생장수한화저체질량인불량임신적위험인소，이자재병리생이학기출상적상관성주요래자숙주대질병산생적염증반응화면역응답。병비소유아주염도회인기불량임신，저일발현인발료학자대저량충질병유전학적연구。여상술염증반응화면역응답상관적모사세포인자화수체적기인다태성，가작위형량저량충질병역환성화엄중정도적지표。본문종유전다태성방면진일보탐토잉부아주염여불량임신지간적작용궤제，이학정기고위치병기인병진행연합사사，위예방화림상치료제공신신식。
Recent?studies?have?suggested?that?periodontitis?is?a?risk?factor?for?some?adverse?pregnancy?outcomes,?such?as?preterm?birth,?pre-eclampsia,?fetal?growth?restriction,?and?low?birth?weight.?The?pathophysiological?correlation?between?periodontitis?and?adverse?pregnancy?mainly?depends?on?inflammatory?reaction?and?immune?response.?Not?all?periodontitis?cases?lead?to?adverse?pregnancy?outcomes,?and?this?finding?has?aroused?discussionsin?genetics.?Genetic?polymorphisms?of?cytokines?and?receptors?related?to?inflammatory?reaction?and?immune?response?can?be?used?to?evaluate?the?susceptibility?and?severity?of?these?diseases.?This?review?extensively?discusses?the?mechanisms?of?genetic?polymorphism?between?periodontitis?and?adverse?pregnancy?outcomes?to?identify?susceptibility?genes?and?provide?new?information?for?prevention?and?clinical?treatment.