CAJ | 학술논문

骨组织形成是一种成骨细胞分泌的细胞外基质再矿化过程，1型胶原是骨组织的主要有机成分，其网状结构有锚定和支持细胞的作用，可提供细胞黏附与增殖的微环境。胶原膜既可为组织再生提供空间屏障，阻止细胞迁移出缺损区从而避免细胞流失；还具有良好的早期血管化作用，可引导血管生长，新生成骨细胞和骨形成相关细胞因子可借新生血管迁移至骨缺损腔内部，促进新骨形成。将胶原膜与骨髓间质干细胞（BMMSC）复合培养可增强成骨细胞的成骨能力，激发BMMSC向成骨细胞转化。胶原膜是BMMSC黏附与生长的良好载体，可作为细胞的支架材料。本文追溯骨髓间质干细胞与胶原膜复合培养的生物学基础和特性，旨在探索骨组织修复重建的方法。
골조직형성시일충성골세포분비적세포외기질재광화과정，1형효원시골조직적주요유궤성분，기망상결구유묘정화지지세포적작용，가제공세포점부여증식적미배경。효원막기가위조직재생제공공간병장，조지세포천이출결손구종이피면세포류실；환구유량호적조기혈관화작용，가인도혈관생장，신생성골세포화골형성상관세포인자가차신생혈관천이지골결손강내부，촉진신골형성。장효원막여골수간질간세포（BMMSC）복합배양가증강성골세포적성골능력，격발BMMSC향성골세포전화。효원막시BMMSC점부여생장적량호재체，가작위세포적지가재료。본문추소골수간질간세포여효원막복합배양적생물학기출화특성，지재탐색골조직수복중건적방법。
?Bone?tissue?formation?is?a?remineralization?process?through?the?extracellular?matrix?secreted?by?osteoblast?cells.?The?main?organic?component?of?bone?tissue?is?type?1?collagen,?and?its?network?structure?supports?cells?and?provides?a?microenvironment?for?cell?adhesion?and?proliferation.?Collagen?membrane?can?provide?a?steric?barrier?for?tissue?regeneration?that?prevents?cells?from?migrating?out?of?the?defect?area?to?avoid?cell?loss;?it?can?also?direct?blood?vessel?growth.?Osteoblast?cells?and?factors?related?to?bone?formation?can?migrate?to?the?bone?defect?cavity?and?promote?new?bone?formation.?Bone?marrow?mesenchymal?stem?cells(BMMSC)?cultured?on?collagen?membrane?can?enhance?the?osteogenic?ability?of?osteoblasts?and?stimulate?the?transformation?of?BMMSC?into?osteoblasts.?Collagen?membrane?is?a?suitable?carrier?of?BMMSC?adhesion?and?growth;?it?can?also?be?used?as?a?scaffold?material?for?cells.?In?this?study,?the?biological?characteristics?of?BMMSC?cultured?on?collagen?membrane?were?traced,?and?methods?for?bone?tissue?repair?and?reconstruction?were?explored.