CAJ | 학술논문

脂联蛋白（APN）是一种主要由脂肪细胞分泌的细胞因子，具有胰岛素增敏以及抗炎和抗动脉粥样硬化等多重作用。人的APN基因位于3q27点位上，约17?kb大小，在结构上与补体C1q和肿瘤坏死因子相似。总体而言，APN与骨代谢关系密切，一部分研究结果支持APN具有促进成骨、抑制破骨的功能，一部分研究则认为APN促进破骨、抑制成骨，Apn基因敲除小鼠的骨表型变化也不是十分明显。目前的研究结果说明，APN调控骨代谢的机制十分复杂，其促成骨或抑制成骨的作用可能与机体所处的状态有关，在不同的条件下，APN对骨代谢的调节可能具有多重性，然而其中的具体机制尚待进一步研究。
지련단백（APN）시일충주요유지방세포분비적세포인자，구유이도소증민이급항염화항동맥죽양경화등다중작용。인적APN기인위우3q27점위상，약17?kb대소，재결구상여보체C1q화종류배사인자상사。총체이언，APN여골대사관계밀절，일부분연구결과지지APN구유촉진성골、억제파골적공능，일부분연구칙인위APN촉진파골、억제성골，Apn기인고제소서적골표형변화야불시십분명현。목전적연구결과설명，APN조공골대사적궤제십분복잡，기촉성골혹억제성골적작용가능여궤체소처적상태유관，재불동적조건하，APN대골대사적조절가능구유다중성，연이기중적구체궤제상대진일보연구。
?Adiponectin?is?the?most?abundant?adipocyte-secreted?adipokine.?It?regulates?energy?homeostasis?and?increases?insulin?sensitivity.?Adiponectin?is?a?multifunctional?protein?with?anti-diabetic,?anti-inflammatory,?and?anti-atherosclerotic?properties.?The?effect?of?adiponectin?on?bone?metabolism?has?been?widely?reported.?However,?its?precise?mechanism?of?action?remains?controversial?and?unclear.?A?few?studies?have?demonstrated?that?adiponectin?can?significantly?stimulate?osteoblastic?differentiation,?promote?osteogenesis,?and?inhibit?bone?resorption.?Conversely,?other?studies?have?shown?opposite?effects.?In?addition,?several?clinical?studies?have?reported?that?plasma?adiponectin?level?is?an?independent?predictor?factor?of?bone?mineral?density.?This?paper?reviews?recent?publications?on?adiponectin?and?bone?metabolism.