国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
International Journal of Blood Transfusion and Hematology
2015年
5期
436-440
,共5页
淋巴瘤,大B-细胞,弥漫性%基因,myc%预后%药物疗法
淋巴瘤,大B-細胞,瀰漫性%基因,myc%預後%藥物療法
림파류,대B-세포,미만성%기인,myc%예후%약물요법
Lymphoma,large B-cell,diffuse%Gene,myc%Prognosis%Drug therapy
弥漫性大B细胞淋巴瘤(DLBCL)为非霍奇金淋巴瘤中的最为常见的类型.原癌基因C-MYC在基因转录调控机制中发挥着重要作用,其与DLBCL的发生、发展及演变转归有重要关系.DLBCL中C-MYC基因的相关研究,可为DLBCL的预后判断及治疗方案的制定等提供可靠的理论依据.笔者拟就C-MYC基因的结构与功能、伴有C-MYC基因异常DLBCL患者的临床特点、C-MYC蛋白在DLBCL中的表达情况、伴有C-MYC基因异常DLBCL患者的预后及疗效进行综述,增加对伴有C-MYC基因异常DLBCL的认识.
瀰漫性大B細胞淋巴瘤(DLBCL)為非霍奇金淋巴瘤中的最為常見的類型.原癌基因C-MYC在基因轉錄調控機製中髮揮著重要作用,其與DLBCL的髮生、髮展及縯變轉歸有重要關繫.DLBCL中C-MYC基因的相關研究,可為DLBCL的預後判斷及治療方案的製定等提供可靠的理論依據.筆者擬就C-MYC基因的結構與功能、伴有C-MYC基因異常DLBCL患者的臨床特點、C-MYC蛋白在DLBCL中的錶達情況、伴有C-MYC基因異常DLBCL患者的預後及療效進行綜述,增加對伴有C-MYC基因異常DLBCL的認識.
미만성대B세포림파류(DLBCL)위비곽기금림파류중적최위상견적류형.원암기인C-MYC재기인전록조공궤제중발휘착중요작용,기여DLBCL적발생、발전급연변전귀유중요관계.DLBCL중C-MYC기인적상관연구,가위DLBCL적예후판단급치료방안적제정등제공가고적이론의거.필자의취C-MYC기인적결구여공능、반유C-MYC기인이상DLBCL환자적림상특점、C-MYC단백재DLBCL중적표체정황、반유C-MYC기인이상DLBCL환자적예후급료효진행종술,증가대반유C-MYC기인이상DLBCL적인식.
Diffuse large B-cell lymphoma(DLBCL) is the most common type of Hodgkin lymphoma.Oncogenes C-MYC plays an important role in gene transcription regulation mechanism,occurrence,development and evolution of DLBCL.Research of C-MYC gene in DLBCL can give us a further,theoretical basis for the judgment of prognosis and treatment of DLBCL and so on.This article reviews literatures on the structure and function of c-myc gene,the clinical characteristics of DLBCL patients with C-MYC gene abnormality,C-MYC protein expression in DLBCL,the treatment and prognosis of DLBCL patients with C-MYC gene abnormality,and hope to increase the understanding of C-MYC gene abnormality in DLBCL.
