国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
International Journal of Blood Transfusion and Hematology
2015年
5期
419-422
,共4页
β连环素%γ连环素%白血病,髓样,急性%肿瘤干细胞
β連環素%γ連環素%白血病,髓樣,急性%腫瘤榦細胞
β련배소%γ련배소%백혈병,수양,급성%종류간세포
Beta catenin%Gamma catenin%Leukemia,myeloid,acute%Neoplastic stem cells
β-及γ-catenin均参与白血病干细胞(LSC)的自我更新过程,在急性髓细胞白血病(AML)中存在异常表达及易位,因此其可能成为清除LSC的新治疗靶点.β-catenin是经典Wnt信号通路中的关键细胞因子,其异常表达及核易位是AML预后不良的独立危险因素.新近研究结果显示,体外抑制β-catenin表达可以杀伤AML及其LSC.而γ-catenin是β-catenin的同源蛋白,在白血病中可以通过β-catenin依赖或非依赖途径发挥生物学作用.笔者就近年来,β及γ-catenin在AML及其LSC中的研究进展进行综述.
β-及γ-catenin均參與白血病榦細胞(LSC)的自我更新過程,在急性髓細胞白血病(AML)中存在異常錶達及易位,因此其可能成為清除LSC的新治療靶點.β-catenin是經典Wnt信號通路中的關鍵細胞因子,其異常錶達及覈易位是AML預後不良的獨立危險因素.新近研究結果顯示,體外抑製β-catenin錶達可以殺傷AML及其LSC.而γ-catenin是β-catenin的同源蛋白,在白血病中可以通過β-catenin依賴或非依賴途徑髮揮生物學作用.筆者就近年來,β及γ-catenin在AML及其LSC中的研究進展進行綜述.
β-급γ-catenin균삼여백혈병간세포(LSC)적자아경신과정,재급성수세포백혈병(AML)중존재이상표체급역위,인차기가능성위청제LSC적신치료파점.β-catenin시경전Wnt신호통로중적관건세포인자,기이상표체급핵역위시AML예후불량적독립위험인소.신근연구결과현시,체외억제β-catenin표체가이살상AML급기LSC.이γ-catenin시β-catenin적동원단백,재백혈병중가이통과β-catenin의뢰혹비의뢰도경발휘생물학작용.필자취근년래,β급γ-catenin재AML급기LSC중적연구진전진행종술.
Overexpression and aberrant nuclear localization of β-catenin and γ-catenin is frequent in acute myelogenous leukemia (AML).They participate in the process of the leukemia stem cell (LSC) self-renewal,and may be important targets for elimination of LSC.β-catenin is a key signal transducer factor in the canonical Wnt pathway,and its abnormal expression and nuclear translocation is an independent risk factor for poor prognosis in AML.Recent studies showed that inhibition of β-catenin can kill AML and its LSC in vitro.γ-catenin,as a homologous protein to β-catenin,plays its biologic role through dependent or non-dependent on the β-catenin pathway.This article reviews literatures on advances of β-catenin and γ-catenin in AML and its LSC.
