中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015年
5期
379-382
,共4页
郁春景%米宝明%翁鸢%潘栋辉%徐宇平%陈飞%陈小元%杨敏%万卫星
鬱春景%米寶明%翁鳶%潘棟輝%徐宇平%陳飛%陳小元%楊敏%萬衛星
욱춘경%미보명%옹연%반동휘%서우평%진비%진소원%양민%만위성
肺肿瘤%肽类,环%精氨酸-甘氨酸-天冬氨酸%氟放射性同位素%体层摄影术,发射型计算机%体层摄影术,X线计算机
肺腫瘤%肽類,環%精氨痠-甘氨痠-天鼕氨痠%氟放射性同位素%體層攝影術,髮射型計算機%體層攝影術,X線計算機
폐종류%태류,배%정안산-감안산-천동안산%불방사성동위소%체층섭영술,발사형계산궤%체층섭영술,X선계산궤
Lung neoplasms%Peptides,cyclic%Arg-Gly-Asp%Fluorine radioisotopes%Tomography,emission-computed%Tomography,X-ray computed
目的 研究18F-氟化铝螯合的聚乙二醇环RGD二肽(Alfatide)在肺癌患者体内的生物学分布及肿瘤组织对18 F-Alfatide的摄取.方法 选取15例疑拟肺癌患者,其中男12例,女3例,平均年龄(56±9)岁,按体质量静脉注射18F-Alfatide 3.7 MBq/kg,静卧60 min后行体部及头部PET/CT扫描,扫描范围从颅顶至股骨上端,勾画ROI并计算SUVmax和SUVmean.对肿瘤石蜡标本切片后进行整合素αvβ3免疫染色分析.采用Spearson等级相关分析18F-Alfatide摄取和αvβ3表达的相关性.结果 15例患者中腺癌7例,鳞状细胞癌7例,小细胞肺癌1例.体内生物学分布结果显示,18 F-Alfatide主要通过肾脏排泄,血液清除快,肌肉及血液本底低,肝、脾及肾脏放射性摄取较高,肺部肿瘤组织具有较高的放射性摄取,肿瘤组织的SUVmax与SUVmean分别为4.27± 1.32与2.75±0.77,T/NT为15.19±9.33;肿瘤组织18F-Alfatide摄取水平随αvβ3表达水平的升高而增加(rs=0.765,P＜0.05).结论 18F-Alfatide具有较好的体内生物学分布特性,相应的PET显像可以反映肿瘤组织的αvβ3表达水平.
目的 研究18F-氟化鋁螯閤的聚乙二醇環RGD二肽(Alfatide)在肺癌患者體內的生物學分佈及腫瘤組織對18 F-Alfatide的攝取.方法 選取15例疑擬肺癌患者,其中男12例,女3例,平均年齡(56±9)歲,按體質量靜脈註射18F-Alfatide 3.7 MBq/kg,靜臥60 min後行體部及頭部PET/CT掃描,掃描範圍從顱頂至股骨上耑,勾畫ROI併計算SUVmax和SUVmean.對腫瘤石蠟標本切片後進行整閤素αvβ3免疫染色分析.採用Spearson等級相關分析18F-Alfatide攝取和αvβ3錶達的相關性.結果 15例患者中腺癌7例,鱗狀細胞癌7例,小細胞肺癌1例.體內生物學分佈結果顯示,18 F-Alfatide主要通過腎髒排洩,血液清除快,肌肉及血液本底低,肝、脾及腎髒放射性攝取較高,肺部腫瘤組織具有較高的放射性攝取,腫瘤組織的SUVmax與SUVmean分彆為4.27± 1.32與2.75±0.77,T/NT為15.19±9.33;腫瘤組織18F-Alfatide攝取水平隨αvβ3錶達水平的升高而增加(rs=0.765,P＜0.05).結論 18F-Alfatide具有較好的體內生物學分佈特性,相應的PET顯像可以反映腫瘤組織的αvβ3錶達水平.
목적 연구18F-불화려오합적취을이순배RGD이태(Alfatide)재폐암환자체내적생물학분포급종류조직대18 F-Alfatide적섭취.방법 선취15례의의폐암환자,기중남12례,녀3례,평균년령(56±9)세,안체질량정맥주사18F-Alfatide 3.7 MBq/kg,정와60 min후행체부급두부PET/CT소묘,소묘범위종로정지고골상단,구화ROI병계산SUVmax화SUVmean.대종류석사표본절편후진행정합소αvβ3면역염색분석.채용Spearson등급상관분석18F-Alfatide섭취화αvβ3표체적상관성.결과 15례환자중선암7례,린상세포암7례,소세포폐암1례.체내생물학분포결과현시,18 F-Alfatide주요통과신장배설,혈액청제쾌,기육급혈액본저저,간、비급신장방사성섭취교고,폐부종류조직구유교고적방사성섭취,종류조직적SUVmax여SUVmean분별위4.27± 1.32여2.75±0.77,T/NT위15.19±9.33;종류조직18F-Alfatide섭취수평수αvβ3표체수평적승고이증가(rs=0.765,P＜0.05).결론 18F-Alfatide구유교호적체내생물학분포특성,상응적PET현상가이반영종류조직적αvβ3표체수평.
Objective To study the biodistribution of 18 F-Alfatide in lung cancer patients.Methods Fifteen patients (12 males,3 females,average age:(56±9) years) with suspicious lung cancer underwent PET/CT imaging.Images were acquired for each patient 60 rain after injection of 18F-Alfatide (3.7 MBq/kg),covering a field of view from the thigh to the skull.SUVmax and SUVmean were calculated with ROI method.Immunohistochemistry test of tumor samples was performed to confirm the expression of integrin αvβ3.The relationship between the accumulation of 18 F-Alfatide and the expression of αv β3 was analyzed by Spearson rank correlation.Results There were 7 patients with squamous cell carcinoma,7 patients with adenocarcinoma and 1 patient with small cell lung cancer.18F-Alfatide was excreted by the kidneys.The radioactivity was quickly eliminated from plasma.The high accumulation of radioactivity was found in the liver,spleen and kidneys.18F-Alfatide PET imaging identified all tumors.The SUVmax and SUVmean of tumors were 4.27± 1.32 and 2.75±0.77 respectively.T/NT ratio was 15.19±9.33.The uptake of 18F-Alfatide in tumor tissues correlated with the expression level of integrin αv β3(rs =0.765,P＜0.05).Conclusion 18F-Alfatide has a favorable property of tissue biodistribution and can be effectively used for αvβ3-positive tumor imaging.
