CAJ | 학술논문

目的多项研究显示microRNAs在肿瘤的进展中扮演着重要作用 ,本研究检测了microRNA-27b在良性前列腺增生和前列腺癌组织中的表达以及其相应的临床意义.方法检测28 例良性前列腺组织和113 例前列腺癌中microRNA-27b的表达 ,并对前列腺癌组织中microRNA-27b与Gleason评分 ,临床分期进行相关分析.结果 microRNA-27b在前列腺癌组织中的表达率显著低于良性前列腺增生的表达率(P<0 .05) ,且microRNA-27b的表达与肿瘤的Gleason评分有相关性(P<0 .05) ,但mi-croRNA-27b在不同临床分期的前列腺癌中无明显差异 ,仅在良性前列腺组织与前列腺癌组织中有显著差异(P<0 .05).结论microRNA-27b在未来或许可作为一种重要的生物学标记物 ,用于前列腺癌的早期诊断和预后评估.
목적 다항연구현시microRNAs재종류적진전중분연착중요작용 ,본연구검측료microRNA-27b재량성전렬선증생화전렬선암조직중적표체이급기상응적림상의의.방법 검측28 례량성전렬선조직화113 례전렬선암중microRNA-27b적표체 ,병대전렬선암조직중microRNA-27b여Gleason평분 ,림상분기진행상관분석.결과 microRNA-27b재전렬선암조직중적표체솔현저저우량성전렬선증생적표체솔(P<0 .05) ,차microRNA-27b적표체여종류적Gleason평분유상관성(P<0 .05) ,단mi-croRNA-27b재불동림상분기적전렬선암중무명현차이 ,부재량성전렬선조직여전렬선암조직중유현저차이(P<0 .05).결론microRNA-27b재미래혹허가작위일충중요적생물학표기물 ,용우전렬선암적조기진단화예후평고.
Objective To investigate the expression of microRNA-27b in different prostate tissues and its clinical signifi-cance .Methods The expression of microRNA-27b in 28 benign prostateic hyperplasia and 113 prostate cancer tissues was de-tected ,and its correlation with Gleason Grading and clinical stages was analyzed .Results The expression of microRNA-27b decreased in prostate cancer compared with that in benign prostatic hyperplasia ,and there was significant difference between the two types of tissues (P<0 .05) .Furthermore ,the expression of microRNA-27b was significantly correlated with the Glea-son Grading (P<0 .05) ,bu not with clinical stages of prostate cancer .Conclusions The microRNA-27b might be a potential biomaker for the early dignosis and prognostic assessment of prostate cancer .